| Literature DB >> 16480259 |
Michael R Wood, Kathy M Schirripa, June J Kim, Bang-Lin Wan, Kathy L Murphy, Richard W Ransom, Raymond S L Chang, Cuyue Tang, Thomayant Prueksaritanont, Theodore J Detwiler, Lisa A Hettrick, Elizabeth R Landis, Yvonne M Leonard, Julie A Krueger, Sidney D Lewis, Douglas J Pettibone, Roger M Freidinger, Mark G Bock.
Abstract
Antagonism of the bradykinin B1 receptor represents a potential treatment for chronic pain and inflammation. Novel antagonists were designed that display low-nanomolar affinity for the human bradykinin B1 receptor and good bioavailability in the rat.Entities:
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Year: 2006 PMID： 16480259 DOI： 10.1021/jm0511280
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446