Literature DB >> 16479151

Substrates of the BRCA1-dependent ubiquitin ligase.

Lea M Starita1, Jeffrey D Parvin.   

Abstract

Discovering the precise function of the breast and ovarian specific tumor suppressor, BRCA1, has proven to be quite complicated. It has been determined that BRCA1, together with BARD1, comprise an E3 ubiquitin ligase. Since it is now known that BRCA1 is an enzyme, the challenge for BRCA1 research is to learn how this enzymatic activity functions in normal breast and ovarian cells in order to suppress cancerous transformation. This review will survey the known ubiquitination substrates of BRCA1 and suggest how these reactions may influence the genomic stability and proliferation of breast cells.

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Year:  2006        PMID： 16479151     DOI： 10.4161/cbt.5.2.2479

Source DB:  PubMed          Journal:  Cancer Biol Ther        ISSN： 1538-4047            Impact factor:   4.742


  20 in total

Review 1.  DUBs at a glance.

Authors:  Keith D Wilkinson
Journal:  J Cell Sci       Date:  2009-07-15       Impact factor: 5.285

Review 2.  BRCA1 and its toolbox for the maintenance of genome integrity.

Authors:  Michael S Y Huen; Shirley M H Sy; Junjie Chen
Journal:  Nat Rev Mol Cell Biol       Date:  2009-12-23       Impact factor: 94.444

3.  Transcriptional regulation of the base excision repair pathway by BRCA1.

Authors:  Tapas Saha; Jeong Keun Rih; Rabindra Roy; Rahul Ballal; Eliot M Rosen
Journal:  J Biol Chem       Date:  2010-02-25       Impact factor: 5.157

4.  Genomic sequence of Spodoptera frugiperda Ascovirus 1a, an enveloped, double-stranded DNA insect virus that manipulates apoptosis for viral reproduction.

Authors:  Dennis K Bideshi; Marie-Véronique Demattei; Florence Rouleux-Bonnin; Karine Stasiak; Yeping Tan; Sylvie Bigot; Yves Bigot; Brian A Federici
Journal:  J Virol       Date:  2006-09-20       Impact factor: 5.103

5.  BRCA1 regulates transforming growth factor-β (TGF-β1) signaling through Gadd45a by enhancing the protein stability of Smad4.

Authors:  Dan Li; Nan Kang; Junfang Ji; Qimin Zhan
Journal:  Mol Oncol       Date:  2015-05-14       Impact factor: 6.603

6.  Negative Regulation of AKT Activation by BRCA1.

Authors:  Tao Xiang; Amiko Ohashi; Yuping Huang; Tej K Pandita; Thomas Ludwig; Simon N Powell; Qin Yang
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701

7.  Toward classification of BRCA1 missense variants using a biophysical approach.

Authors:  Pamela J E Rowling; Rebecca Cook; Laura S Itzhaki
Journal:  J Biol Chem       Date:  2010-04-08       Impact factor: 5.157

8.  Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repair.

Authors:  Yunfu Lin; John H Wilson
Journal:  Mol Cell Biol       Date:  2007-06-25       Impact factor: 4.272

9.  The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability.

Authors:  S Lüddecke; N Ertych; A Stenzinger; W Weichert; T Beissbarth; J Dyczkowski; J Gaedcke; O Valerius; G H Braus; M Kschischo; H Bastians
Journal:  Oncogene       Date:  2015-08-24       Impact factor: 9.867

10.  BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses.

Authors:  Huchun Li; Masayuki Sekine; Seyha Seng; Shalom Avraham; Hava Karsenty Avraham
Journal:  PLoS One       Date:  2009-09-21       Impact factor: 3.240
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