Literature DB >> 20029420

BRCA1 and its toolbox for the maintenance of genome integrity.

Michael S Y Huen1, Shirley M H Sy, Junjie Chen.   

Abstract

The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition, recent proteomic and genetic studies have revealed the presence of distinct BRCA1 complexes in vivo, each of which governs a specific cellular response to DNA damage. Thus, BRCA1 is emerging as the master regulator of the genome through its ability to execute and coordinate various aspects of the DNA damage response.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 20029420      PMCID： PMC3899800          DOI： 10.1038/nrm2831

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  123 in total

1.  DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.

Authors:  E P Rogakou; D R Pilch; A H Orr; V S Ivanova; W M Bonner
Journal:  J Biol Chem       Date:  1998-03-06       Impact factor: 5.157

2.  Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.

Authors:  R M Hofmann; C M Pickart
Journal:  Cell       Date:  1999-03-05       Impact factor: 41.582

3.  The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression.

Authors:  X Yu; L C Wu; A M Bowcock; A Aronheim; R Baer
Journal:  J Biol Chem       Date:  1998-09-25       Impact factor: 5.157

4.  BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation.

Authors:  Xiaowei Chen; Cletus A Arciero; Chunrong Wang; Dominique Broccoli; Andrew K Godwin
Journal:  Cancer Res       Date:  2006-05-15       Impact factor: 12.701

5.  Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers.

Authors:  T H Thai; F Du; J T Tsan; Y Jin; A Phung; M A Spillman; H F Massa; C Y Muller; R Ashfaq; J M Mathis; D S Miller; B J Trask; R Baer; A M Bowcock
Journal:  Hum Mol Genet       Date:  1998-02       Impact factor: 6.150

6.  Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1.

Authors:  J E Meza; P S Brzovic; M C King; R E Klevit
Journal:  J Biol Chem       Date:  1999-02-26       Impact factor: 5.157

7.  Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.

Authors:  J Chen; D P Silver; D Walpita; S B Cantor; A F Gazdar; G Tomlinson; F J Couch; B L Weber; T Ashley; D M Livingston; R Scully
Journal:  Mol Cell       Date:  1998-09       Impact factor: 17.970

8.  BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.

Authors:  S F Anderson; B P Schlegel; T Nakajima; E S Wolpin; J D Parvin
Journal:  Nat Genet       Date:  1998-07       Impact factor: 38.330

9.  A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

Authors:  Jolanta Polanowska; Julie S Martin; Tatiana Garcia-Muse; Mark I R Petalcorin; Simon J Boulton
Journal:  EMBO J       Date:  2006-04-20       Impact factor: 11.598

10.  Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.

Authors:  Simon Bekker-Jensen; Claudia Lukas; Risa Kitagawa; Fredrik Melander; Michael B Kastan; Jiri Bartek; Jiri Lukas
Journal:  J Cell Biol       Date:  2006-04-17       Impact factor: 10.539
View more
  251 in total

1.  Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.

Authors:  Kumar Somyajit; Shreelakshmi Subramanya; Ganesh Nagaraju
Journal:  J Biol Chem       Date:  2011-12-13       Impact factor: 5.157

2.  BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.

Authors:  Reena Shakya; Latarsha J Reid; Colleen R Reczek; Francesca Cole; Dieter Egli; Chyuan-Sheng Lin; Dirk G deRooij; Steffen Hirsch; Kandasamy Ravi; James B Hicks; Matthias Szabolcs; Maria Jasin; Richard Baer; Thomas Ludwig
Journal:  Science       Date:  2011-10-28       Impact factor: 47.728

Review 3.  BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies.

Authors:  Seth M Dever; E Railey White; Matthew C T Hartman; Kristoffer Valerie
Journal:  Cell Cycle       Date:  2012-02-15       Impact factor: 4.534

4.  The C-terminal proteolytic fragment of the breast cancer susceptibility type 1 protein (BRCA1) is degraded by the N-end rule pathway.

Authors:  Zhizhong Xu; Roshani Payoe; Richard P Fahlman
Journal:  J Biol Chem       Date:  2012-01-18       Impact factor: 5.157

Review 5.  Characterizing ubiquitination sites by peptide-based immunoaffinity enrichment.

Authors:  Daisy Bustos; Corey E Bakalarski; Yanling Yang; Junmin Peng; Donald S Kirkpatrick
Journal:  Mol Cell Proteomics       Date:  2012-06-23       Impact factor: 5.911

Review 6.  Ubiquitin signalling in DNA replication and repair.

Authors:  Helle D Ulrich; Helen Walden
Journal:  Nat Rev Mol Cell Biol       Date:  2010-06-16       Impact factor: 94.444

7.  Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II.

Authors:  Paul Verbruggen; Marius Ruf; Gjon Blakqori; Anna K Överby; Martin Heidemann; Dirk Eick; Friedemann Weber
Journal:  J Biol Chem       Date:  2010-11-30       Impact factor: 5.157

8.  MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination.

Authors:  Fan Zhang; Gregory Bick; Jung-Young Park; Paul R Andreassen
Journal:  J Cell Sci       Date:  2012-10-04       Impact factor: 5.285

Review 9.  DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity.

Authors:  Henning Willers; Liliana Gheorghiu; Qi Liu; Jason A Efstathiou; Lori J Wirth; Mechthild Krause; Cläre von Neubeck
Journal:  Semin Radiat Oncol       Date:  2015-05-14       Impact factor: 5.934

10.  The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate.

Authors:  Beom-Jun Kim; Doug W Chan; Sung Yun Jung; Yue Chen; Jun Qin; Yi Wang
Journal:  Cell Rep       Date:  2017-05-30       Impact factor: 9.423
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.