| Literature DB >> 16476993 |
Suzanne U Emerson1, Pilar Clemente-Casares1, Nasser Moiduddin1, Vidya A Arankalle2, Udana Torian1, Robert H Purcell1.
Abstract
Monolayers of Hep G2/C3A cells were inoculated with genotype 1 Hepatitis E virus (HEV) mixed with either anti-HEV or an appropriate control. After 5 or 6 days, cell monolayers were stained with anti-HEV and infected cells were identified by immunofluorescence microscopy and counted. Anti-HEV from vaccinated or infected rhesus monkeys neutralized the virus, as did mAbs that recognized epitopes on the C terminus of a recombinant vaccine protein. Antibodies were broadly cross-reactive, since convalescent serum from animals infected with any one of the four mammalian genotypes all neutralized the genotype 1 virus.Entities:
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Year: 2006 PMID： 16476993 DOI： 10.1099/vir.0.81545-0
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891