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Literature DB >> 16474933

Association between the MLH1 gene and longevity.

Dong Jo Kim¹, Sang Mi Yi, Seung Yeon Lee, Heun Soo Kang, Yoon-Ho Choi, Yeong Wook Song, Sang Chul Park.

Abstract

Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found here that MLH1 is associated with longevity by comparing a centenarian group with a control group. Our data indicate a critical role for MLH1 in longevity.

Entities: Disease Gene

Mesh：

Substances：

Year: 2006 PMID： 16474933 DOI： 10.1007/s00439-006-0148-7

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

6 in total

1. A simple system for automated two-dimensional electrophoresis: applications to genetic testing.

Authors: R K Dhanda; W M Smith; C B Scott; C Eng; J Vijg
Journal: Genet Test Date: 1998

2. Involvement of mammalian MLH1 in the apoptotic response to peroxide-induced oxidative stress.

Authors: R A Hardman; C A Afshari; J C Barrett
Journal: Cancer Res Date: 2001-02-15 Impact factor: 12.701

3. Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations.

Authors: Q Pang; T A Prolla; R M Liskay
Journal: Mol Cell Biol Date: 1997-08 Impact factor: 4.272

4. Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.

Authors: P V Shcherbakova; T A Kunkel
Journal: Mol Cell Biol Date: 1999-04 Impact factor: 4.272

Review 5. Effect of aging on DNA repair and skin carcinogenesis: a minireview of population-based studies.

Authors: Q Wei
Journal: J Investig Dermatol Symp Proc Date: 1998-08

6. Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair.

Authors: T A Prolla; S M Baker; A C Harris; J L Tsao; X Yao; C E Bronner; B Zheng; M Gordon; J Reneker; N Arnheim; D Shibata; A Bradley; R M Liskay
Journal: Nat Genet Date: 1998-03 Impact factor: 38.330

6 in total

1. Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Authors: Mette Soerensen; Serena Dato; Qihua Tan; Mikael Thinggaard; Rabea Kleindorp; Marian Beekman; Rune Jacobsen; H Eka D Suchiman; Anton J M de Craen; Rudi G J Westendorp; Stefan Schreiber; Tinna Stevnsner; Vilhelm A Bohr; P Eline Slagboom; Almut Nebel; James W Vaupel; Kaare Christensen; Matt McGue; Lene Christiansen
Journal: Exp Gerontol Date: 2012-03-03 Impact factor: 4.032

2. Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis.

Authors: Birgit Debrabant; Mette Soerensen; Friederike Flachsbart; Serena Dato; Jonas Mengel-From; Tinna Stevnsner; Vilhelm A Bohr; Torben A Kruse; Stefan Schreiber; Almut Nebel; Kaare Christensen; Qihua Tan; Lene Christiansen
Journal: Eur J Hum Genet Date: 2014-02-12 Impact factor: 4.246

Review 6. Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest-Old Population.

Authors: Yeo Jin Kim; Hyun Soo Kim; Young Rok Seo
Journal: Oxid Med Cell Longev Date: 2018-05-03 Impact factor: 6.543

6 in total

Association between the MLH1 gene and longevity.

1. A simple system for automated two-dimensional electrophoresis: applications to genetic testing.

2. Involvement of mammalian MLH1 in the apoptotic response to peroxide-induced oxidative stress.

3. Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations.

4. Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.

Review 5. Effect of aging on DNA repair and skin carcinogenesis: a minireview of population-based studies.

6. Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair.

1. Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

2. Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis.

Review 3. The quest for genetic determinants of human longevity: challenges and insights.

Review 4. The multifaceted roles of DNA repair and replication proteins in aging and obesity.

5. Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia.

Review 6. Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest-Old Population.