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Literature DB >> 33529944

The multifaceted roles of DNA repair and replication proteins in aging and obesity.

Abstract

Efficient mechanisms for genomic maintenance (i.e., DNA repair and DNA replication) are crucial for cell survival. Aging and obesity can lead to the dysregulation of genomic maintenance proteins/pathways and are significant risk factors for the development of cancer, metabolic disorders, and other genetic diseases. Mutations in genes that code for proteins involved in DNA repair and DNA replication can also exacerbate aging- and obesity-related disorders and lead to the development of progeroid diseases. In this review, we will discuss the roles of various DNA repair and replication proteins in aging and obesity as well as investigate the possible mechanisms by which aging and obesity can lead to the dysregulation of these proteins and pathways.

Entities: Chemical

Keywords: Aging; DNA repair; DNA replication; Genetic instability; Obesity

Mesh：

Year: 2021 PMID： 33529944 PMCID： PMC7941874 DOI： 10.1016/j.dnarep.2021.103049

Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856

231 in total

1. Aging: a theory based on free radical and radiation chemistry.

Authors: D HARMAN
Journal: J Gerontol Date: 1956-07

2. Telomere dysfunction as a cause of genomic instability in Werner syndrome.

Authors: Laure Crabbe; Anna Jauch; Colleen M Naeger; Heidi Holtgreve-Grez; Jan Karlseder
Journal: Proc Natl Acad Sci U S A Date: 2007-02-06 Impact factor: 11.205

3. Msh2 promoter region hypermethylation as a marker of aging-related deterioration in old retired female breeder mice.

Authors: Juan C Conde-Pérezprina; Armando Luna-López; Norma E López-Diazguerrero; Pablo Damián-Matsumura; Alejandro Zentella; Mina Königsberg
Journal: Biogerontology Date: 2008-05-07 Impact factor: 4.277

4. Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly.

Authors: Jonas Mengel-From; Mikael Thinggaard; Christine Dalgård; Kirsten Ohm Kyvik; Kaare Christensen; Lene Christiansen
Journal: Hum Genet Date: 2014-06-06 Impact factor: 4.132

5. Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK.

Authors: S J Araújo; F Tirode; F Coin; H Pospiech; J E Syväoja; M Stucki; U Hübscher; J M Egly; R D Wood
Journal: Genes Dev Date: 2000-02-01 Impact factor: 11.361

1. Bioinformatic identification of genomic instability-associated lncRNAs signatures for improving the clinical outcome of cervical cancer by a prognostic model.

Authors: Jian Zhang; Nan Ding; Yongxing He; Chengbin Tao; Zhongzhen Liang; Wenhu Xin; Qianyun Zhang; Fang Wang
Journal: Sci Rep Date: 2021-10-22 Impact factor: 4.379

1 in total

The multifaceted roles of DNA repair and replication proteins in aging and obesity.

1. Aging: a theory based on free radical and radiation chemistry.

2. Telomere dysfunction as a cause of genomic instability in Werner syndrome.

3. Msh2 promoter region hypermethylation as a marker of aging-related deterioration in old retired female breeder mice.

4. Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly.

5. Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK.

Review 6. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.

Review 7. Roles of Werner syndrome protein in protection of genome integrity.

Review 8. Is there a link between DNA polymerase beta and cancer?

Review 9. Functional regulation of FEN1 nuclease and its link to cancer.

10. CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence.

1. Bioinformatic identification of genomic instability-associated lncRNAs signatures for improving the clinical outcome of cervical cancer by a prognostic model.