Literature DB >> 1647194

Human responses to inhaled capsaicin are not inhibited by granisetron.

N B Choudry1, J R McEwan, E A Lavender, A J Williams, R W Fuller.   

Abstract

Cough is a common respiratory symptom, the mechanism of which is poorly understood. In this study the role of 5-HT3 receptors was investigated. Capsaicin-induced cough and increase in airways resistance were measured in six male volunteers before and after infusion with granisetron 160 micrograms kg-1 or placebo. Neither cough nor the increase in respiratory resistance was altered by the active treatment. These results suggest that 5-HT3 receptors are not involved in these two respiratory responses to inhaled capsaicin in humans.

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Year:  1991        PMID： 1647194      PMCID： PMC1368361          DOI： 10.1111/j.1365-2125.1991.tb05538.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  14 in total

Review 1.  Physiology and treatment of cough.

Authors:  R W Fuller; D M Jackson
Journal:  Thorax       Date:  1990-06       Impact factor: 9.139

Review 2.  Neuropharmacology of emesis induced by anti-cancer therapy.

Authors:  P L Andrews; W G Rapeport; G J Sanger
Journal:  Trends Pharmacol Sci       Date:  1988-09       Impact factor: 14.819

3.  Effect of inhaled and systemic opiates on responses to inhaled capsaicin in humans.

Authors:  R W Fuller; J A Karlsson; N B Choudry; N B Pride
Journal:  J Appl Physiol (1985)       Date:  1988-09

4.  Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs.

Authors:  B P Richardson; G Engel; P Donatsch; P A Stadler
Journal:  Nature       Date:  1985 Jul 11-17       Impact factor: 49.962

5.  A pharmacokinetic study of granisetron (BRL 43694A), a selective 5-HT3 receptor antagonist: correlation with anti-emetic response.

Authors:  J Carmichael; B M Cantwell; C M Edwards; B D Zussman; S Thompson; W G Rapeport; A L Harris
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

6.  Binding of the 5-HT3 ligand, [3H]GR65630, to rat area postrema, vagus nerve and the brains of several species.

Authors:  G J Kilpatrick; B J Jones; M B Tyers
Journal:  Eur J Pharmacol       Date:  1989-01-10       Impact factor: 4.432

7.  Prevention of emesis in patients receiving cytotoxic drugs by GR38032F, a selective 5-HT3 receptor antagonist.

Authors:  D Cunningham; J Hawthorn; A Pople; J C Gazet; H T Ford; T Challoner; R C Coombes
Journal:  Lancet       Date:  1987-06-27       Impact factor: 79.321

8.  Bronchoconstrictor response to inhaled capsaicin in humans.

Authors:  R W Fuller; C M Dixon; P J Barnes
Journal:  J Appl Physiol (1985)       Date:  1985-04

9.  Involvement of central serotonergic mechanisms in the cough reflex.

Authors:  J Kamei; T Hosokawa; S Yanaura; T Hukuhara
Journal:  Jpn J Pharmacol       Date:  1986-12

10.  Separation of cough and reflex bronchoconstriction by inhaled local anaesthetics.

Authors:  N B Choudry; R W Fuller; N Anderson; J A Karlsson
Journal:  Eur Respir J       Date:  1990-05       Impact factor: 16.671
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  3 in total

1.  Modulation of capsaicin induced airway reflexes in humans: effect of monoamine oxidase inhibition.

Authors:  N B Choudry; J Studham; D Harland; R W Fuller
Journal:  Br J Clin Pharmacol       Date:  1993-02       Impact factor: 4.335

2.  Effects of glycopyrrolate on capsaicin-induced cough in normal volunteers treated with captopril.

Authors:  M van Wyk; D K Sommers; J R Snyman
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

3.  Review: Effect of drugs on human cough reflex sensitivity to inhaled capsaicin.

Authors:  Peter V Dicpinigaitis
Journal:  Cough       Date:  2012-11-12
  3 in total

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