Literature DB >> 3839291

Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs.

B P Richardson, G Engel, P Donatsch, P A Stadler.   

Abstract

We describe a new class of drugs that selectively block serotonin M-receptors on peripheral neurones. Because of their high affinity, some of these drugs are the most potent of any pharmacological class yet reported. They have allowed the identification of three M-receptor subtypes, one of which is responsible for mediating the painful effects of serotonin in humans.

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Year:  1985        PMID： 3839291     DOI： 10.1038/316126a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  191 in total

1.  The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors.

Authors:  Karla P Zeitz; Nicolas Guy; Annika B Malmberg; Sahera Dirajlal; William J Martin; Linda Sun; Douglas W Bonhaus; Cheryl L Stucky; David Julius; Allan I Basbaum
Journal:  J Neurosci       Date:  2002-02-01       Impact factor: 6.167

2.  Pharmacological characterization of 5-hydroxytryptamine-induced excitation of afferent cervical vagus nerve in anaesthetized rats.

Authors:  M Yoshioka; T Ikeda; M Abe; H Togashi; M Minami; H Saito
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

3.  Identification and distribution of 5-HT3 recognition sites in the rat gastrointestinal tract.

Authors:  S Champaneria; B Costall; R J Naylor; D W Robertson
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

Review 4.  5-HT3 receptor antagonists and migraine therapy.

Authors:  M D Ferrari
Journal:  J Neurol       Date:  1991       Impact factor: 4.849

5.  Contractile 5-HT1 receptors in human isolated pial arterioles: correlation with 5-HT1D binding sites.

Authors:  E Hamel; D Bouchard
Journal:  Br J Pharmacol       Date:  1991-01       Impact factor: 8.739

6.  Properties of 5-hydroxytryptamine3 receptor-gated currents in adult rat dorsal root ganglion neurones.

Authors:  B Robertson; S Bevan
Journal:  Br J Pharmacol       Date:  1991-01       Impact factor: 8.739

7.  The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons.

Authors:  A Dumuis; M Sebben; J Bockaert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-10       Impact factor: 3.000

8.  Serotonin (5-HT) enhances hippocampal noradrenaline (NA) release: evidence for facilitatory 5-HT receptors within the CNS.

Authors:  T J Feuerstein; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-07       Impact factor: 3.000

9.  Effects of MDL 72222 and methiothepin on carotid vascular responses to 5-hydroxytryptamine in the pig: evidence for the presence of "5-hydroxytryptamine1-like" receptors.

Authors:  P R Saxena; D J Duncker; A H Bom; J Heiligers; P D Verdouw
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-07       Impact factor: 3.000

10.  Characterization of 5-HT3 receptors of N1E-115 neuroblastoma cells by use of the influx of the organic cation [14C]-guanidinium.

Authors:  H Bönisch; M Barann; J Graupner; M Göthert
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739
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