| Literature DB >> 16466802 |
Bianca Jupp1, John P Williams, Yasvir A Tesiram, Milosh Vosmansky, Terence J O'Brien.
Abstract
The rat electrical kindling model has been widely utilized in epilepsy research. This study aimed to identify the optimum "MRI compatible" bipolar stimulating and recording electrodes to enable serial MRI acquisition in this model. Two types of custom-made electrodes (gold and carbon) were compared with commercial platinum-iridium alloy electrodes for suitability based on size, effect on image quality and kindling induction. The custom-made gold electrodes, based on these parameters, were found to be most suitable. These electrodes enable the study of epileptogenesis utilizing MRI in this model of temporal lobe epilepsy (TLE).Entities:
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Year: 2006 PMID： 16466802 DOI： 10.1016/j.jneumeth.2005.12.024
Source DB: PubMed Journal: J Neurosci Methods ISSN： 0165-0270 Impact factor: 2.390