Literature DB >> 164668

Hamster alpha-amanitine-resistant RNA polymerase II able to transcribe polyoma virus genome in somatic cell hybrids.

P Amati, F Blasi, U Di Porzio, A Riccio, C Traboni.   

Abstract

A hamster cell line resistant to alpha-amanitine has been isolated (alpha-am-r, BHK-T6-G-1). Cell extracts of this mutant have an alpha-amanitine-resistant RNA polymerase II (nucleosidetriphosphate: RNA nucleotidyl-transferase, EC 2.7.7.6) activity as shown by DEAE-cellulose column chromatography. This mutation is dominant in interspecific hybrids with 3T3 mouse cells. In such hybrids polyoma virus can grow with equal efficiency in the presence or absence of the drug, thus indicating that the RNA polymerase of the unsusceptible parental cell can participate in the correct transcription of the viral genome.

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Year:  1975        PMID： 164668      PMCID： PMC432395          DOI： 10.1073/pnas.72.2.753

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  The effect of rifampicin on mitochondrial RNA polymerase from rat liver.

Authors:  M N. Gadaleta; M Greco; C Saccone
Journal:  FEBS Lett       Date:  1970-09-18       Impact factor: 4.124

2.  SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.

Authors:  J W LITTLEFIELD
Journal:  Science       Date:  1964-08-14       Impact factor: 47.728

Review 3.  Mammalian RNA polymerases.

Authors:  S T Jacob
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1973

4.  Inhibition by -amanitin of simian virus 40-specific ribonucleic acid synthesis in nuclei of infected monkey cells.

Authors:  A H Jackson; B Sugden
Journal:  J Virol       Date:  1972-11       Impact factor: 5.103

5.  The interaction of polyoma virus with mouse-hamster somatic hybrid cells.

Authors:  C Basilico; Y Matsuya; H Green
Journal:  Virology       Date:  1970-06       Impact factor: 3.616

6.  Selection of morphologically normal cell lines from polyoma-transformed BHK21/13 hamster fibroblasts.

Authors:  G Marin; J W Littlefield
Journal:  J Virol       Date:  1968-01       Impact factor: 5.103

7.  Origin of the thymidine kinase induced by polyoma virus in productively infected cells.

Authors:  C Basilico; Y Matsuya; H Green
Journal:  J Virol       Date:  1969-02       Impact factor: 5.103

8.  Mammalian cells with altered forms of RNA polymerase II.

Authors:  V L Chan; G F Whitmore; L Siminovitch
Journal:  Proc Natl Acad Sci U S A       Date:  1972-11       Impact factor: 11.205

9.  Permeability control in animal cells by polyenes: a possibility.

Authors:  G Medoff; C N Kwan; D Schlessinger; G S Kobayashi
Journal:  Antimicrob Agents Chemother       Date:  1973-03       Impact factor: 5.191

10.  Polyoma virus gene activity during lytic infection and in transformed animal cells.

Authors:  M A Martin; D Axelrod
Journal:  Science       Date:  1969-04-04       Impact factor: 47.728
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  12 in total

Review 1.  Amanitins in virus research.

Authors:  G Campadelli-Fiume
Journal:  Arch Virol       Date:  1978       Impact factor: 2.574

2.  Biogenesis of poxviruses: role for the DNA-dependent RNA polymerase II of the host during expression of late functions.

Authors:  M Silver; G McFadden; S Wilton; S Dales
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

3.  Ribonucleic acid synthesis dependent on exogenous triphosphates in nystatin-treated cells of of Kluyveromyces latis.

Authors:  G Badaracco; G Cassani
Journal:  Antimicrob Agents Chemother       Date:  1976-05       Impact factor: 5.191

4.  Temperature-sensitive RNA polymerase II mutations in Chinese hamster ovary cells.

Authors:  C J Ingles
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

5.  Lethal and amanitin-resistance mutations in the Caenorhabditis elegans ama-1 and ama-2 genes.

Authors:  T M Rogalski; A M Bullerjahn; D L Riddle
Journal:  Genetics       Date:  1988-10       Impact factor: 4.562

6.  Fine-structure genetics of ama-1, an essential gene encoding the amanitin-binding subunit of RNA polymerase II in Caenorhabditis elegans.

Authors:  A M Bullerjahn; D L Riddle
Journal:  Genetics       Date:  1988-10       Impact factor: 4.562

Review 7.  Genetics of eukaryotic RNA polymerases I, II, and III.

Authors:  J Archambault; J D Friesen
Journal:  Microbiol Rev       Date:  1993-09

8.  Myogenic differentiation of L6 rat myoblasts: evidence for pleiotropic effects on myogenesis by RNA polymerase II mutations to alpha-amanitin resistance.

Authors:  M M Crerar; R Leather; E David; M L Pearson
Journal:  Mol Cell Biol       Date:  1983-05       Impact factor: 4.272

9.  Altered sensitivity of Rous sarcoma virus transformed cells to inhibition of RNA synthesis by alpha-amanitin.

Authors:  M Dinowitz; T J Lindell; A O'Malley
Journal:  Arch Virol       Date:  1977       Impact factor: 2.574

10.  Synthesis of low molecular weight RNA components A, C and D by polymerase II in alpha-amanitin-resistant hamster cells.

Authors:  E G Jensen; P Hellung-Larsen; S Frederiksen
Journal:  Nucleic Acids Res       Date:  1979-01       Impact factor: 16.971
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