Literature DB >> 16466435

The Exeter Family Study of Childhood Health (EFSOCH): study protocol and methodology.

Bridget Knight1, Beverley M Shields, Andrew T Hattersley.   

Abstract

The Exeter Family Study of Childhood Health is a prospective study, set up to test the fetal insulin hypothesis, and to identify genetic polymorphisms that play a role in determining birthweight and early postnatal growth. We recruited 1017 families from a postcode-defined area in central Exeter. Specific inclusion criteria were established to obtain a homogeneous, non-diabetic, UK Caucasian cohort. Detailed anthropometric measurements were taken from both parents at 28 weeks' gestation, and from their children at birth, 12 weeks, 1 year and 2 years of age. Insulin and other biochemical analysis were measured in fasting parental samples and an umbilical cord blood sample taken at delivery. Parental and offspring DNA were extracted to allow molecular genetic analysis of candidate genes implicated in fetal growth. This comprehensive data set is available on a disease-free cohort, and detailed preparatory work has ensured high levels of quality control. The study would welcome collaboration within strict confidentiality rules.

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Year:  2006        PMID： 16466435     DOI： 10.1111/j.1365-3016.2006.00701.x

Source DB:  PubMed          Journal:  Paediatr Perinat Epidemiol        ISSN： 0269-5022            Impact factor:   3.980


  38 in total

1.  Paternal insulin resistance and its association with umbilical cord insulin concentrations.

Authors:  B M Shields; B Knight; M Turner; B Wilkins-Wall; L Shakespeare; R J Powell; M Hannemann; P M Clark; C S Yajnik; A T Hattersley
Journal:  Diabetologia       Date:  2006-05-16       Impact factor: 10.122

2.  A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.

Authors:  Vijay Panicker; Christie Cluett; Beverley Shields; Anna Murray; Kirstie S Parnell; John R B Perry; Michael N Weedon; Andrew Singleton; Dena Hernandez; Jonathan Evans; Claire Durant; Luigi Ferrucci; David Melzer; Ponnusamy Saravanan; Theo J Visser; Graziano Ceresini; Andrew T Hattersley; Bijay Vaidya; Colin M Dayan; Timothy M Frayling
Journal:  J Clin Endocrinol Metab       Date:  2008-05-20       Impact factor: 5.958

3.  Fetal thyroid hormone level at birth is associated with fetal growth.

Authors:  Beverley M Shields; Beatrice A Knight; Anita Hill; Andrew T Hattersley; Bijay Vaidya
Journal:  J Clin Endocrinol Metab       Date:  2011-03-16       Impact factor: 5.958

4.  Offspring birthweight is not associated with paternal insulin resistance.

Authors:  B Knight; B M Shields; A Hill; R J Powell; A Round; W Hamilton; A T Hattersley
Journal:  Diabetologia       Date:  2006-09-05       Impact factor: 10.122

5.  Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk.

Authors:  Katherine A Fawcett; Eleanor Wheeler; Andrew P Morris; Sally L Ricketts; Göran Hallmans; Olov Rolandsson; Allan Daly; Jon Wasson; Alan Permutt; Andrew T Hattersley; Benjamin Glaser; Paul W Franks; Mark I McCarthy; Nicholas J Wareham; Manjinder S Sandhu; Inês Barroso
Journal:  Diabetes       Date:  2009-12-22       Impact factor: 9.461

6.  Fetal Genotype and Maternal Glucose Have Independent and Additive Effects on Birth Weight.

Authors:  Alice E Hughes; Michael Nodzenski; Robin N Beaumont; Octavious Talbot; Beverley M Shields; Denise M Scholtens; Bridget A Knight; William L Lowe; Andrew T Hattersley; Rachel M Freathy
Journal:  Diabetes       Date:  2018-02-20       Impact factor: 9.461

7.  Type 2 diabetes risk alleles are associated with reduced size at birth.

Authors:  Rachel M Freathy; Amanda J Bennett; Susan M Ring; Beverley Shields; Christopher J Groves; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Cecilia M Lindgren; Hana Lango; John R B Perry; Anneli Pouta; Aimo Ruokonen; Elina Hyppönen; Chris Power; Paul Elliott; David P Strachan; Marjo-Riitta Järvelin; George Davey Smith; Mark I McCarthy; Timothy M Frayling; Andrew T Hattersley
Journal:  Diabetes       Date:  2009-02-19       Impact factor: 9.461

8.  A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.

Authors:  Rachel M Freathy; Susan M Ring; Beverley Shields; Bruna Galobardes; Beatrice Knight; Michael N Weedon; George Davey Smith; Timothy M Frayling; Andrew T Hattersley
Journal:  Hum Mol Genet       Date:  2009-05-09       Impact factor: 6.150

9.  Genome-wide association analysis identifies 20 loci that influence adult height.

Authors:  Michael N Weedon; Hana Lango; Cecilia M Lindgren; Chris Wallace; David M Evans; Massimo Mangino; Rachel M Freathy; John R B Perry; Suzanne Stevens; Alistair S Hall; Nilesh J Samani; Beverly Shields; Inga Prokopenko; Martin Farrall; Anna Dominiczak; Toby Johnson; Sven Bergmann; Jacques S Beckmann; Peter Vollenweider; Dawn M Waterworth; Vincent Mooser; Colin N A Palmer; Andrew D Morris; Willem H Ouwehand; Jing Hua Zhao; Shengxu Li; Ruth J F Loos; Inês Barroso; Panagiotis Deloukas; Manjinder S Sandhu; Eleanor Wheeler; Nicole Soranzo; Michael Inouye; Nicholas J Wareham; Mark Caulfield; Patricia B Munroe; Andrew T Hattersley; Mark I McCarthy; Timothy M Frayling
Journal:  Nat Genet       Date:  2008-04-06       Impact factor: 38.330

10.  Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.

Authors:  Rachel M Freathy; Nicholas J Timpson; Debbie A Lawlor; Anneli Pouta; Yoav Ben-Shlomo; Aimo Ruokonen; Shah Ebrahim; Beverley Shields; Eleftheria Zeggini; Michael N Weedon; Cecilia M Lindgren; Hana Lango; David Melzer; Luigi Ferrucci; Giuseppe Paolisso; Matthew J Neville; Fredrik Karpe; Colin N A Palmer; Andrew D Morris; Paul Elliott; Marjo-Riitta Jarvelin; George Davey Smith; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
Journal:  Diabetes       Date:  2008-03-17       Impact factor: 9.461
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