| Literature DB >> 16464579 |
Erich L Grimm1, Christine Brideau, Nathalie Chauret, Chi-Chung Chan, Daniel Delorme, Yves Ducharme, Diane Ethier, Jean-Pierre Falgueyret, Richard W Friesen, Jocelyne Guay, Pierre Hamel, Denis Riendeau, Chantal Soucy-Breau, Philip Tagari, Yves Girard.
Abstract
Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.Entities:
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Year: 2006 PMID： 16464579 DOI： 10.1016/j.bmcl.2006.01.085
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823