| Literature DB >> 16459146 |
Zoltán Fehérvari1, Tomoyuki Yamaguchi, Shimon Sakaguchi.
Abstract
Interleukin-2 (IL-2) is a well-known T-cell growth factor, which is traditionally implicated in the agonistic stimulation of immune responses. Recent work, however, has uncovered an unexpected function of this cytokine. In particular, IL-2 appears crucial to maintaining peripheral tolerance by supporting the survival and function of CD25+ CD4+ regulatory T cells. A recent study examining the role of IL-2 in the peripheral generation of regulatory T cells from apparently naïve T cells has gone some way to reconciling the seemingly opposing functions of this cytokine.Entities:
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Year: 2006 PMID： 16459146 DOI： 10.1016/j.it.2006.01.005
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687