OBJECTIVE: The purpose of this study was to examine the value of performing a detailed examination of the fetus as part of the routine 11 to 14 weeks' ultrasound scan in a 2-stage screening process for major structural defects in low-risk pregnancies. STUDY DESIGN: This was a prospective study in 1148 singleton pregnancies at 11 to 14 weeks of gestation using a combination of transabdominal and transvaginal sonography to estimate the sensitivity of the first and second trimester ultrasound scan in the detection of major anomalies. RESULTS: Seven of the 14 major anomalies were detected at the 11 to 14 weeks scan, and an additional 6 at the second trimester scan. The sensitivity of the early anatomic examination and the overall sensitivity of the 2-stage screening were 50% and 92.8%, respectively. Nuchal translucency was increased in 5 of the 14 (35.7%) abnormal fetuses and in 1 of the 4 cases (25%) with major heart defects. CONCLUSION: Detailed, structured examination of fetal anatomy during the routine 11 to 14 weeks' scan can detect half of major structural defects in low-risk pregnancies.
OBJECTIVE: The purpose of this study was to examine the value of performing a detailed examination of the fetus as part of the routine 11 to 14 weeks' ultrasound scan in a 2-stage screening process for major structural defects in low-risk pregnancies. STUDY DESIGN: This was a prospective study in 1148 singleton pregnancies at 11 to 14 weeks of gestation using a combination of transabdominal and transvaginal sonography to estimate the sensitivity of the first and second trimester ultrasound scan in the detection of major anomalies. RESULTS: Seven of the 14 major anomalies were detected at the 11 to 14 weeks scan, and an additional 6 at the second trimester scan. The sensitivity of the early anatomic examination and the overall sensitivity of the 2-stage screening were 50% and 92.8%, respectively. Nuchal translucency was increased in 5 of the 14 (35.7%) abnormal fetuses and in 1 of the 4 cases (25%) with major heart defects. CONCLUSION: Detailed, structured examination of fetal anatomy during the routine 11 to 14 weeks' scan can detect half of major structural defects in low-risk pregnancies.
Authors: Leonie Baken; Melek Rousian; Anton H J Koning; Gouke J Bonsel; Alex J Eggink; Jérôme M J Cornette; Ernst M Schoonderwaldt; Margreet Husen-Ebbinge; Katinka K Teunissen; Peter J van der Spek; Eric A P Steegers; Niek Exalto Journal: Reprod Sci Date: 2014-01-18 Impact factor: 3.060
Authors: Edward Andrew Springhall; Daniel Lorber Rolnik; Maya Reddy; Sujatha Ganesan; Maria Maxfield; Jayshree Ramkrishna; Simon Meagher; Mark Teoh; Fabricio da Silva Costa Journal: Australas J Ultrasound Med Date: 2018-08-22