Literature DB >> 16458521

Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi.

Ana Cristina Lima Leite1, Renata Souza de Lima, Diogo Rodrigo de M Moreira, Marcos Veríssimo de O Cardoso, Ana Carolina Gouveia de Brito, Luciene Maria Farias Dos Santos, Marcelo Zaldini Hernandes, Alice Costa Kiperstok, Ricardo Santana de Lima, Milena B P Soares.   

Abstract

A novel series of thiosemicarbazone and aminoacyl-thiazolidones derivatives were synthesized. Their structure suggests that these compounds could have anti-Trypanosoma cruzi activity. Biological evaluation indicates that some of these compounds are able to inhibit the growth of T. cruzi in concentrations non-cytotoxic to mammalian cells. Docking studies were carried out in order to investigate the binding pattern of these compounds for the T. cruzi cruzain (TCC) protein, and these showed a significant correlation with experimental data.

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Year:  2006        PMID： 16458521     DOI： 10.1016/j.bmc.2006.01.034

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  13 in total

1.  A theoretical study of red-shifting and blue-shifting hydrogen bonds occurring between imidazolidine derivatives and PEG/PVP polymers.

Authors:  Boaz G Oliveira; Maria C A Lima; Ivan R Pitta; Suely L Galdino; Marcelo Z Hernandes
Journal:  J Mol Model       Date:  2009-06-12       Impact factor: 1.810

Review 2.  Tau as a therapeutic target in neurodegenerative disease.

Authors:  Diana S Himmelstein; Sarah M Ward; Jody K Lancia; Kristina R Patterson; Lester I Binder
Journal:  Pharmacol Ther       Date:  2012-07-10       Impact factor: 12.310

3.  1-(3-Chloro-phen-yl)-4,4,6-trimethyl-3,4-dihydro-pyrimidine-2(1H)-thione.

Authors:  Bohari M Yamin; Halima Farag Salem
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-08

4.  1-(4-Chloro-phen-yl)-4,4,6-trimethyl-3,4-dihydro-pyrimidine-2(1H)-thione.

Authors:  Aamer Saeed; Michael Bolte
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-01-23

5.  1-(3-Fluoro-phen-yl)-4,4,6-trimethyl-3,4-dihydro-pyrimidine-2(1H)-thione.

Authors:  Bohari M Yamin; Ruhana L Lawi; Halima F Salem
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-06-25

6.  Methyl 6-(4-chloro-phen-yl)-2,4-dimethyl-1,3-dioxo-1,2,3,4,6,6a,7,12b-octa-hydro-chromeno[4',3':4,5]pyrano[2,3-d]pyrimidine-6a-carboxyl-ate.

Authors:  J Kanchanadevi; G Anbalagan; G Sivakumar; M Bakthadoss; V Manivannan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-07-09

7.  Syntheses, spectral characterization, and antimicrobial studies on the coordination compounds of metal ions with schiff base containing both aliphatic and aromatic hydrazide moieties.

Authors:  Dinesh Kumar; Silky Chadda; Jyoti Sharma; Parveen Surain
Journal:  Bioinorg Chem Appl       Date:  2013-10-03       Impact factor: 7.778

Review 8.  Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase.

Authors:  Hugo Cerecetto; Mercedes González
Journal:  Pharmaceuticals (Basel)       Date:  2010-03-25

9.  Effects of a thiosemicarbazide camphene derivative on Trichophyton mentagrophytes.

Authors:  Mirian Ueda Yamaguchi; Ana Paula Barbosa da Silva; Tânia Ueda-Nakamura; Benedito Prado Dias Filho; Cleuza Conceição da Silva; Celso Vataru Nakamura
Journal:  Molecules       Date:  2009-05-13       Impact factor: 4.411

10.  Design and Synthesis of New Benzophenone Derivatives with In Vivo Anti-Inflammatory Activity through Dual Inhibition of Edema and Neutrophil Recruitment.

Authors:  Jaqueline P Januario; Thiago B de Souza; Stefânia N Lavorato; Tatiane C S Maiolini; Olívia S Domingos; João L Baldim; Laís R S Folquitto; Marisi G Soares; Daniela A Chagas-Paula; Danielle F Dias; Marcelo H Dos Santos
Journal:  Molecules       Date:  2018-07-26       Impact factor: 4.411
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