Literature DB >> 1645839

Identification of phosphatidylinositol-specific phospholipase C activity in Listeria monocytogenes: a novel type of virulence factor?

J Mengaud1, C Braun-Breton, P Cossart.   

Abstract

A phospholipase C which cleaves phosphatidylinositol and glycosylphosphatidylinositol (GPI) anchors was identified in Listeria monocytogenes. This 36 kDa protein is encoded by the gene plcA, and is homologous to the Bacillus cereus, Bacillus thuringiensis and eukaryotic phosphatidylinositol-specific phospholipases C (PI-PLC). Expression of the plcA gene in Escherichia coli correlates with the appearance of PI-PLC activity in the cells. In Listeria monocytogenes, the activity is secreted to the culture medium. PI-PLC activity was only found in the two pathogenic species of the genus Listeria, namely L. monocytogenes and L. ivanovii. PI-PLC activity was lost and virulence decreased when the plcA gene was disrupted in the chromosome. This suggests that the PI-PLC of L. monocytogenes might be involved in virulence.

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Year:  1991        PMID： 1645839     DOI： 10.1111/j.1365-2958.1991.tb02118.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  74 in total

Review 1.  Molecular determinants of Listeria monocytogenes pathogenesis.

Authors:  D A Portnoy; T Chakraborty; W Goebel; P Cossart
Journal:  Infect Immun       Date:  1992-04       Impact factor: 3.441

2.  Listeria monocytogenes infection of P388D1 macrophages results in a biphasic NF-kappaB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IkappaBalpha and IkappaBbeta degradation.

Authors:  N Hauf; W Goebel; F Fiedler; Z Sokolovic; M Kuhn
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

3.  Listeria monocytogenes phosphatidylinositol-specific phospholipase C has evolved for virulence by greatly reduced activity on GPI anchors.

Authors:  Zhengyu Wei; Lauren A Zenewicz; Howard Goldfine
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-23       Impact factor: 11.205

4.  The global regulatory proteins LetA and RpoS control phospholipase A, lysophospholipase A, acyltransferase, and other hydrolytic activities of Legionella pneumophila JR32.

Authors:  Markus Broich; Kerstin Rydzewski; Tamara L McNealy; Reinhard Marre; Antje Flieger
Journal:  J Bacteriol       Date:  2006-02       Impact factor: 3.490

Review 5.  Listeria pathogenesis and molecular virulence determinants.

Authors:  J A Vázquez-Boland; M Kuhn; P Berche; T Chakraborty; G Domínguez-Bernal; W Goebel; B González-Zorn; J Wehland; J Kreft
Journal:  Clin Microbiol Rev       Date:  2001-07       Impact factor: 26.132

6.  The virulence gene cluster of Listeria monocytogenes is also present in Listeria ivanovii, an animal pathogen, and Listeria seeligeri, a nonpathogenic species.

Authors:  E Gouin; J Mengaud; P Cossart
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441

7.  Promotion of cytotoxic T-cell generation in mixed leukocyte culture by phosphatidylinositol-specific phospholipase C from Bacillus thuringiensis.

Authors:  S M Rahman; M Y Pu; H Yi; K Ohkusu; M Kato; K Isobe; R Taguchi; H Ikezawa; I Nakashima
Journal:  Infect Immun       Date:  1995-01       Impact factor: 3.441

8.  The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread.

Authors:  G A Smith; H Marquis; S Jones; N C Johnston; D A Portnoy; H Goldfine
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441

9.  Induction of cytokines in phagocytic mammalian cells infected with virulent and avirulent Listeria strains.

Authors:  M Kuhn; W Goebel
Journal:  Infect Immun       Date:  1994-02       Impact factor: 3.441

10.  Identification and purification of novel internalin-related proteins in Listeria monocytogenes and Listeria ivanovii.

Authors:  A Lingnau; T Chakraborty; K Niebuhr; E Domann; J Wehland
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441
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