| Literature DB >> 16455256 |
S D Guile1, J R Bantick, D R Cheshire, M E Cooper, A M Davis, D K Donald, R Evans, C Eyssade, D D Ferguson, S Hill, R Hutchinson, A H Ingall, L P Kingston, I Martin, B P Martin, R T Mohammed, C Murray, M W D Perry, R H Reynolds, P V Thorne, D J Wilkinson, J Withnall.
Abstract
A novel series of potent blockers of the monocarboxylate transporter, MCT1, is disclosed. From very potent but lipophilic lead compounds, systematic changes to all parts of the molecule, targeting reduction in log D, afforded compounds with significantly improved overall properties. These compounds show potent immunomodulatory activity.Entities:
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Year: 2006 PMID： 16455256 DOI： 10.1016/j.bmcl.2006.01.024
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823