Literature DB >> 26257580

One-pot directed alkylation/deprotection strategy for the synthesis of substituted pyrrole[3,4-d]pyridazinones.

Reji N Nair1, Thomas D Bannister1.   

Abstract

In the course of an SAR study of pyrrole[3,4-d]pyridazinones we optimized conditions for a one pot directed lithiation / alkylation reaction that also promoted in situ cleavage of a Boc-protecting group on the pyrrole ring. The efficiency of the process allowed access to a number of substituted analogues of interest as possible antitumor agents.

Entities:  

Keywords:  antitumour agents; fused-ring systems; halogenation; heterocycles; lithiation; metalation; protecting groups

Year:  2015        PMID： 26257580      PMCID： PMC4524656          DOI： 10.1002/ejoc.201403491

Source DB:  PubMed          Journal:  European J Org Chem        ISSN： 1099-0690


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