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Literature DB >> 16452445

NnrA is required for full virulence and regulates several Brucella melitensis denitrification genes.

Valérie Haine¹, Marie Dozot, Jacques Dornand, Jean-Jacques Letesson, Xavier De Bolle.

Abstract

We identified two regulators of denitrification genes in Brucella melitensis 16M: NarR, which regulates the nitrate reductase (nar) operon, and NnrA, which is involved in the expression of the last three reductases of the denitrification pathway (nirK, norB, and nosZ). NnrA is required for virulence in mice and for intracellular resistance to nitric oxide.

Entities: Chemical Gene Species

Mesh：

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Year: 2006 PMID： 16452445 PMCID： PMC1367225 DOI： 10.1128/JB.188.4.1615-1619.2006

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

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