| Literature DB >> 16444670 |
Shen-Chieh Chou1, Molly C Everngam, George Sturtz, John J Beck.
Abstract
The isolation, characterization and bioactivity testing of compounds from Lomatium californicum (Nutt.) are described. Ethyl acetate and hexane extracts of the roots of L. californicum were subjected to vacuum liquid chromatography (VLC), flash column chromatography (FCC) and separation by normal- and reverse-phase high-performance liquid chromatography (HPLC). Six compounds were isolated successfully and characterized by 1D and 2D nuclear magnetic resonance (NMR) experimentation. The bioactivity of the known compounds (+)-falcarindiol, coniferyl ferulate, ferulic acid and (Z)-ligustilide were confirmed against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. The known compounds senkyunolide I and trans-neocnidilide were also isolated but in too small a quantity for similar testing. Copyright 2006 John Wiley & Sons, Ltd.Entities:
Mesh:
Substances:
Year: 2006 PMID: 16444670 DOI: 10.1002/ptr.1828
Source DB: PubMed Journal: Phytother Res ISSN: 0951-418X Impact factor: 5.878