BACKGROUND: A frequent polymorphism of the brain-derived neurotrophic factor (BDNF) gene (val(66)met) has been suggested to modulate hippocampal neuronal plasticity and has been associated with individual variations in emotional reactivity traits and episodic memory. METHODS: The hippocampal formation was outlined in high-resolution anatomical magnetic resonance imaging (MRI) data in a sample of 36 healthy volunteers and compared between individuals as a function of the presence of the met-BDNF allele. Both whole-brain volume corrected and uncorrected data were tested for effects of genotype, sex, and age. RESULTS: The met-BDNF allele was associated with an 11% reduction in the volume of the hippocampal formation. CONCLUSIONS: In spite of a relatively small sample size, the presence of the met-BDNF allele was found associated with a reduced volume of the hippocampal formation in healthy volunteers and may represent a vulnerability factor for the development of disease processes associated with the dysfunction of this brain region.
BACKGROUND: A frequent polymorphism of the brain-derived neurotrophic factor (BDNF) gene (val(66)met) has been suggested to modulate hippocampal neuronal plasticity and has been associated with individual variations in emotional reactivity traits and episodic memory. METHODS: The hippocampal formation was outlined in high-resolution anatomical magnetic resonance imaging (MRI) data in a sample of 36 healthy volunteers and compared between individuals as a function of the presence of the met-BDNF allele. Both whole-brain volume corrected and uncorrected data were tested for effects of genotype, sex, and age. RESULTS: The met-BDNF allele was associated with an 11% reduction in the volume of the hippocampal formation. CONCLUSIONS: In spite of a relatively small sample size, the presence of the met-BDNF allele was found associated with a reduced volume of the hippocampal formation in healthy volunteers and may represent a vulnerability factor for the development of disease processes associated with the dysfunction of this brain region.
Authors: Elizabeth P Hayden; Daniel N Klein; Lea R Dougherty; Thomas M Olino; Margaret W Dyson; C Emily Durbin; Haroon I Sheikh; Shiva M Singh Journal: Psychol Sci Date: 2010-10-04
Authors: Megan A Miller; Regina L Leckie; Shannon D Donofry; Peter J Gianaros; Kirk I Erickson; Stephen B Manuck; Kathryn A Roecklein Journal: Hippocampus Date: 2015-01-20 Impact factor: 3.899
Authors: Nancy A Dennis; Roberto Cabeza; Anna C Need; Sheena Waters-Metenier; David B Goldstein; Kevin S LaBar Journal: Hippocampus Date: 2010-05-20 Impact factor: 3.899
Authors: Jiska S Peper; Hugo G Schnack; Rachel M Brouwer; G Caroline M Van Baal; Eneda Pjetri; Eszter Székely; Marieke van Leeuwen; Stéphanie M van den Berg; D Louis Collins; Alan C Evans; Dorret I Boomsma; René S Kahn; Hilleke E Hulshoff Pol Journal: Hum Brain Mapp Date: 2009-07 Impact factor: 5.038