A systematic review of the role of proton pump inhibitors for symptoms of laryngopharyngeal reflux.

. Proton pump inhibitors are currently used widely for the treatment of laryngopharyngeal reflux. . This systematic review assessed the efficacy of proton pump inhibitors in the treatment of symptoms of laryngopharyngeal reflux. . Outcome measures used to assess efficacy of proton pump inhibitors included endoscopic laryngeal signs and pH recordings. .Only two small randomized-controlled trials included patients with objective evidence of reflux in the 24-h ambulatory oesophageal pH monitoring. . Pooled analysis of these two randomized-controlled trials failed to show any effect in favour of treatment with proton pump inhibitors. .Further randomized-controlled trials are required to ascertain the role of proton pump inhibitors in the treatment of laryngopharyngeal reflux.