| Literature DB >> 16439201 |
JoAnn M Sekiguchi1, David O Ferguson.
Abstract
A major pathway for repair of DNA double-strand breaks is nonhomologous end-joining (NHEJ). In this issue of Cell, and report the discovery of a new NHEJ factor called Cernunnos-XLF. Both groups report that this protein is mutated in a rare inherited human syndrome characterized by severe immunodeficiency, developmental delay, and hypersensitivity to agents that cause DNA double-strand breaks.Entities:
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Year: 2006 PMID： 16439201 DOI： 10.1016/j.cell.2006.01.010
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582