| Literature DB >> 16439200 |
Ravichandran Ramasamy1, Shi Fang Yan, Ann Marie Schmidt.
Abstract
The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene expression.Entities:
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Year: 2006 PMID： 16439200 DOI： 10.1016/j.cell.2006.01.002
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582