Literature DB >> 16437701

Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-alpha treatment?

Mehmet Sahin1, Mehmet Isler, Altug Senol, Mustafa Demirci, Zeynep Dilek Aydin.   

Abstract

Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fasciolopsiasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus (HCV) infection. We report here the case of a male patient who acquired Fasciola hepatica infection after an initial response to IFN-alpha therapy with a favorable outcome.

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Year:  2005        PMID： 16437701      PMCID： PMC4727215          DOI： 10.3748/wjg.v11.i48.7688

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  12 in total

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Journal:  Semin Liver Dis       Date:  1997       Impact factor: 6.115

Review 2.  Immunopathogenesis of hepatitis C viral infection: Th1/Th2 responses and the role of cytokines.

Authors:  P M Jacobson Brown; M G Neuman
Journal:  Clin Biochem       Date:  2001-05       Impact factor: 3.281

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Authors:  E Jaeckel; M Cornberg; H Wedemeyer; T Santantonio; J Mayer; M Zankel; G Pastore; M Dietrich; C Trautwein; M P Manns
Journal:  N Engl J Med       Date:  2001-11-15       Impact factor: 91.245

4.  Immunodiagnosis of human fascioliasis by an enzyme-linked immunosorbent assay (ELISA) and a micro-ELISA.

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Journal:  Clin Diagn Lab Immunol       Date:  2001-01

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Authors:  S M Kamal; J W Rasenack; L Bianchi; A Al Tawil; K El Sayed Khalifa; T Peter; H Mansour; W Ezzat; M Koziel
Journal:  Gastroenterology       Date:  2001-09       Impact factor: 22.682

6.  Fasciola hepatica infection downregulates Th1 responses in mice.

Authors:  S M O'Neill; M T Brady; J J Callanan; G Mulcahy; P Joyce; K H Mills; J P Dalton
Journal:  Parasite Immunol       Date:  2000-03       Impact factor: 2.280

7.  IFN-gamma and IFN-alpha posttranscriptionally down-regulate the IL-4-induced IL-4 receptor gene expression.

Authors:  E Y So; H H Park; C E Lee
Journal:  J Immunol       Date:  2000-11-15       Impact factor: 5.422

Review 8.  The role of immune responses in the pathogenesis of hepatitis C virus infection.

Authors:  M J Koziel
Journal:  J Viral Hepat       Date:  1997       Impact factor: 3.728

Review 9.  Biological basis for the clinical use of interferon.

Authors:  F Dianzani
Journal:  Gut       Date:  1993       Impact factor: 23.059

10.  T- and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus--positive blood donors without viremia.

Authors:  M Lechmann; H G Ihlenfeldt; I Braunschweiger; G Giers; G Jung; B Matz; R Kaiser; T Sauerbruch; U Spengler
Journal:  Hepatology       Date:  1996-10       Impact factor: 17.425
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