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Literature DB >> 16436734

Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice.

Masaki Fujita¹, Qing Ye, Hiroshi Ouchi, Eiji Harada, Ichiro Inoshima, Kazuyoshi Kuwano, Yoichi Nakanishi.

Abstract

The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.

Entities: Chemical Disease Species

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Year: 2006 PMID： 16436734 PMCID： PMC1366885 DOI： 10.1128/AAC.50.2.739-743.2006

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

24 in total

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2. Serum surfactant protein D is increased in acute and chronic inflammation in mice.

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Authors: D E Carney; C J Lutz; A L Picone; L A Gatto; N S Ramamurthy; L M Golub; S R Simon; B Searles; A Paskanik; K Snyder; C Finck; H J Schiller; G F Nieman
Journal: Circulation Date: 1999-07-27 Impact factor: 29.690

5. Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension.

Authors: M Fujita; J M Shannon; C G Irvin; K A Fagan; C Cool; A Augustin; R J Mason
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6. Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms.

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8. Effects of tetracyclines on the pathologic activity of endotoxin: in vitro and in vivo studies.

Authors: L Shapira; V Barak; W A Soskolne; A Halabi; A Stabholz
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9. Collagenase and gelatinase activities in bronchoalveolar lavage fluids during bleomycin-induced lung injury.

Authors: J Bakowska; I Y Adamson
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10. Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice.

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21 in total

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Authors: W B LaRivière; S Liao; S A McMurtry; K Oshima; X Han; F Zhang; S Yan; S M Haeger; M Ransom; J A Bastarache; R J Linhardt; E P Schmidt; Y Yang
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2020-04-22 Impact factor: 5.464

2. Targeted drug delivery to emphysematous lungs: Inhibition of MMPs by doxycycline loaded nanoparticles.

Authors: Vaideesh Parasaram; Nasim Nosoudi; Renee J LeClair; Andrew Binks; Naren Vyavahare
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3. Surfactant protein-D regulates effector cell function and fibrotic lung remodeling in response to bleomycin injury.

Authors: Yoshinori Aono; Julie G Ledford; Sambuddho Mukherjee; Hirohisa Ogawa; Yasuhiko Nishioka; Saburo Sone; Michael F Beers; Paul W Noble; Jo Rae Wright
Journal: Am J Respir Crit Care Med Date: 2011-12-28 Impact factor: 21.405

4. Pharmacokinetics of doxycycline in adults with cystic fibrosis.

Authors: Paul M Beringer; Heather Owens; Albert Nguyen; Debbie Benitez; Adupa Rao; David Z D'Argenio
Journal: Antimicrob Agents Chemother Date: 2011-10-24 Impact factor: 5.191

5. A novel profibrotic mechanism mediated by TGFβ-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells.

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Journal: J Pathol Date: 2015-04-08 Impact factor: 7.996