Literature DB >> 16435641

Comparison of drops versus spray administration of intranasal midazolam in two- and three-year-old children for dental sedation.

Robert E Primosch1, Marcio Guelmann.   

Abstract

PURPOSE: The purpose of this retrospective record review of 2- and 3-year-old dental patients receiving intranasal midazolam (INM) was to compare drops vs spray administration to behavioral outcomes observed for agent acceptance during administration and for agent efficacy during parental separation, local anesthesia injection, and delivery of restorative dentistry.
METHODS: Temperament and attachment scores based on adaptability and approachability determinants judged by the parent and interactive and Frankl behavior rating scores determined by the operator were used to compare preoperative behavioral characteristics between the 2 groups. The Ohio State Behavioral Rating Scale (OSBRS) and the Frankl behavior rating scale were used to determine intraoperative behavioral outcomes for agent acceptance and efficacy.
RESULTS: Analysis of 64 sedation records revealed that the 2 groups had similar preoperative behavioral characteristics. Improvements in the Frankl behavioral rating scores were observed during the sedation, but no statistically significant difference between the drops and spray groups was measured using the OSBRS. For the procedural event of drug administration, however, the spray group demonstrated a statistically significant reduction (P=.025) in aversive behaviors when compared to drops administration as measured by the OSBRS. This finding was observed, even though the volume of spray was greater than used in the drops group.
CONCLUSIONS: Spray administration of INM produced significantly less aversive behavior than administering drops in 2- to 3-year-old dental patients of similar behavioral characteristics. The effectiveness of the conscious sedation technique was not influenced by the method of nasal administration. This study suggested that the use of a commercially available atomizer improved patient acceptance of INM administration but did not influence agent efficacy compared to drops administration for 2- to 3-year-old dental patients in an office setting.

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Year:  2005        PMID: 16435641

Source DB:  PubMed          Journal:  Pediatr Dent        ISSN: 0164-1263            Impact factor:   1.874


  9 in total

1.  A randomized clinical trial comparing oral, aerosolized intranasal, and aerosolized buccal midazolam.

Authors:  Eileen J Klein; Julie C Brown; Ana Kobayashi; Daniel Osincup; Kristy Seidel
Journal:  Ann Emerg Med       Date:  2011-10       Impact factor: 5.721

2.  Safety and physiologic effects of intranasal midazolam and nitrous oxide inhalation based sedation in children visiting Saveetha Dental College and Hospitals, India.

Authors:  Neethu Ann Preethy; Sujatha Somasundaram
Journal:  Bioinformation       Date:  2022-01-31

3.  Comparison of the Sedative Effect of Inhaled Nitrous Oxide and Intranasal Midazolam in Behavior Management and Pain Perception of Pediatric Patients: A Split-mouth Randomized Controlled Clinical Trial.

Authors:  Navaneetha Krishnan Srinivasan; Pradeep Karunagaran; Veerale Panchal; Emg Subramanian
Journal:  Int J Clin Pediatr Dent       Date:  2021

4.  Intranasal Midazolam Premedication for Anxiolysis in Children Reluctant to Receive Nitrous Oxide Sedation via Nasal Hood: An In Vivo Randomized Control Trial.

Authors:  Iqbal Musani; Sabina Bhure; Shikha Choubey; Smita Iqbal Musani; Safa Surve
Journal:  Int J Clin Pediatr Dent       Date:  2021

5.  Comparison of Intranasal Dexmedetomidine with Intranasal Clonidine as a Premedication in Surgery.

Authors:  Gurkaran Kaur Sidhu; Seema Jindal; Gurpreet Kaur; Gurpreet Singh; Kewal Krishan Gupta; Shobha Aggarwal
Journal:  Indian J Pediatr       Date:  2016-06-04       Impact factor: 1.967

Review 6.  Pediatric dental sedation: challenges and opportunities.

Authors:  Travis M Nelson; Zheng Xu
Journal:  Clin Cosmet Investig Dent       Date:  2015-08-26

7.  Comparison of Oral and Intranasal Midazolam/Ketamine Sedation in 3-6-year-old Uncooperative Dental Patients.

Authors:  Masoud Fallahinejad Ghajari; Ghassem Ansari; Ali Asghar Soleymani; Shahnaz Shayeghi; Faezeh Fotuhi Ardakani
Journal:  J Dent Res Dent Clin Dent Prospects       Date:  2015-06-10

8.  Conscious sedation procedures using intravenous midazolam for dental care in patients with different cognitive profiles: a prospective study of effectiveness and safety.

Authors:  Valérie Collado; Denise Faulks; Emmanuel Nicolas; Martine Hennequin
Journal:  PLoS One       Date:  2013-08-05       Impact factor: 3.240

9.  Intranasal midazolam may prevent gagging reflex: a case report.

Authors:  Meral Arslan Malkoc; Necla Demir; Zehra Ileri; Aybuke Erdur; Seza Apiliogullari
Journal:  J Oral Maxillofac Res       Date:  2013-10-01
  9 in total

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