| Literature DB >> 16433519 |
Jayasree Seayad1, Abdul Majeed Seayad, Benjamin List.
Abstract
A catalytic asymmetric Pictet-Spengler reaction has been developed, wherein treating substituted tryptamines with an aldehyde in the presence of a catalytic amount of a chiral phosphoric acid provides the corresponding tetrahydro-beta-carboline derivatives in high yields and enantiomeric excesses. The reaction works well with both aliphatic and aromatic aldehydes.Entities:
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Year: 2006 PMID： 16433519 DOI： 10.1021/ja057444l
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419