| Literature DB >> 16432195 |
Wei Huang1, Yungang He, Haifeng Wang, Ying Wang, Yangfan Liu, Yi Wang, Xun Chu, Ying Wang, Liang Xu, Yayun Shen, Xiaoyan Xiong, Hui Li, Bo Wen, Ji Qian, Wentao Yuan, Chenhui Zhang, Yi Wang, Hongquan Jiang, Guoping Zhao, Zhu Chen, Li Jin.
Abstract
The discovery of the block-like structure of linkage disequilibrium (LD) in human populations holds the promise of delineating the etiology of common diseases. However, understanding the magnitude, mechanism, and utility of between-population LD sharing is critical for future genome-wide association studies. In this study, substantial LD sharing between six non-African populations was observed, although much less between African-American and non-African, based on 20,000 SNPs of chromosome 21. We also demonstrated the respective roles of recombination and demographic events in shaping LD sharing. Furthermore, we showed that the haplotype-tagged SNPs chosen from one population are portable to the others in East Asia. Therefore, we concluded that the magnitude of LD sharing between human populations justifies the use of representative populations for selecting haplotype-tagged SNPs in genome-wide association studies of complex diseases.Entities:
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Year: 2006 PMID： 16432195 PMCID： PMC1360575 DOI： 10.1073/pnas.0510360103
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205