AIM: To assess the clinical significance of Hepatitis B virus (HBV) DNA localization in the liver tissue of patients with positive HBsAg and negative viremia. METHODS: HBV virological parameters of 33 HBsAg positive chronic hepatitis patients, including seromarkers and HBV DNA amplification in both sera and liver biopsies, were evaluated. RESULTS: Ten patients had negative viremia and positive HBV DNA in their liver biopsies. Most of them had HBeAg-negative/HBeAb-positive chronic hepatitis. Their liver biochemical and histopathological profiles were different from the viremic patients. Their disease pattern was designated as "hepatitis B in situ". CONCLUSION: Hepatitis B in situ is a consequential entity which can be missed in clinical practice. It is a new clinical pattern of chronic HBV infection that considers HBV in liver biopsy and adds a new indication for antiviral therapy.
AIM: To assess the clinical significance of Hepatitis B virus (HBV) DNA localization in the liver tissue of patients with positive HBsAg and negative viremia. METHODS:HBV virological parameters of 33 HBsAg positive chronic hepatitispatients, including seromarkers and HBV DNA amplification in both sera and liver biopsies, were evaluated. RESULTS: Ten patients had negative viremia and positive HBV DNA in their liver biopsies. Most of them had HBeAg-negative/HBeAb-positive chronic hepatitis. Their liver biochemical and histopathological profiles were different from the viremic patients. Their disease pattern was designated as "hepatitis B in situ". CONCLUSION:Hepatitis B in situ is a consequential entity which can be missed in clinical practice. It is a new clinical pattern of chronic HBV infection that considers HBV in liver biopsy and adds a new indication for antiviral therapy.
Authors: I Cacciola; T Pollicino; G Squadrito; G Cerenzia; D Villari; R de Franchis; T Santantonio; S Brancatelli; G Colucci; G Raimondo Journal: Hepatology Date: 2000-02 Impact factor: 17.425
Authors: K Ishak; A Baptista; L Bianchi; F Callea; J De Groote; F Gudat; H Denk; V Desmet; G Korb; R N MacSween Journal: J Hepatol Date: 1995-06 Impact factor: 25.083
Authors: Moataza H Omran; Basma E Fotouh; Samar S Youssef; Noha E Ibrahim; Wael Nabil; El-Sayed M Mahdy; Wafaa G Shosha; Mostafa K El-Awady Journal: World J Hepatol Date: 2013-03-27
Authors: Mostafa K El Awady; Mohamed A Anany; Gamal Esmat; Naglaa Zayed; Ashraf A Tabll; Amr Helmy; Abdel Rahman El Zayady; Mohga S Abdalla; Hayat M Sharada; Maissa El Raziky; Wafaa El Akel; Shadia Abdalla; Noha G Bader El Din Journal: J Gastroenterol Hepatol Date: 2011-05 Impact factor: 4.029