Literature DB >> 16418746

Digital genetics: unravelling the genetic basis of evolution.

Christoph Adami1.   

Abstract

Digital genetics, or the genetics of digital organisms, is a new field of research that has become possible as a result of the remarkable power of evolution experiments that use computers. Self-replicating strands of computer code that inhabit specially prepared computers can mutate, evolve and adapt to their environment. Digital organisms make it easy to conduct repeatable, controlled experiments, which have a perfect genetic 'fossil record'. This allows researchers to address fundamental questions about the genetic basis of the evolution of complexity, genome organization, robustness and evolvability, and to test the consequences of mutations, including their interaction and recombination, on the fate of populations and lineages.

Mesh:

Year:  2006        PMID: 16418746     DOI: 10.1038/nrg1771

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN: 1471-0056            Impact factor:   53.242


  30 in total

1.  Historical contingency affects signaling strategies and competitive abilities in evolving populations of simulated robots.

Authors:  Steffen Wischmann; Dario Floreano; Laurent Keller
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-03       Impact factor: 11.205

Review 2.  New insights into bacterial adaptation through in vivo and in silico experimental evolution.

Authors:  Thomas Hindré; Carole Knibbe; Guillaume Beslon; Dominique Schneider
Journal:  Nat Rev Microbiol       Date:  2012-03-27       Impact factor: 60.633

3.  Evolution of music by public choice.

Authors:  Robert M MacCallum; Matthias Mauch; Austin Burt; Armand M Leroi
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-18       Impact factor: 11.205

4.  Adaptive walks on the fitness landscape of music.

Authors:  Christoph Adami
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-09       Impact factor: 11.205

5.  Introduction to focus issue: genetic interactions.

Authors:  Daniel Segrè; Christopher J Marx
Journal:  Chaos       Date:  2010-06       Impact factor: 3.642

6.  Evolutionary history of a specialized p450 propane monooxygenase.

Authors:  Rudi Fasan; Yergalem T Meharenna; Christopher D Snow; Thomas L Poulos; Frances H Arnold
Journal:  J Mol Biol       Date:  2008-06-28       Impact factor: 5.469

7.  Gene divergence and pathway duplication in the metabolic network of yeast and digital organisms.

Authors:  P Gerlee; T Lundh; B Zhang; A R A Anderson
Journal:  J R Soc Interface       Date:  2009-03-18       Impact factor: 4.118

8.  Selection methods regulate evolution of cooperation in digital evolution.

Authors:  Pawel Lichocki; Dario Floreano; Laurent Keller
Journal:  J R Soc Interface       Date:  2013-10-23       Impact factor: 4.118

9.  The dynamics of adaptation on correlated fitness landscapes.

Authors:  Sergey Kryazhimskiy; Gasper Tkacik; Joshua B Plotkin
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-26       Impact factor: 11.205

Review 10.  Systems-biology approaches for predicting genomic evolution.

Authors:  Balázs Papp; Richard A Notebaart; Csaba Pál
Journal:  Nat Rev Genet       Date:  2011-08-02       Impact factor: 53.242

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