OBJECTIVE: To test the hypothesis that male compared with female prematurely born infants would have worse lung function at follow up. DESIGN: Prospective follow up study. SETTING:Tertiary neonatal intensive care units PATIENTS: Seventy six infants, mean (SD) gestational age 26.4 (1.5) weeks, from the United Kingdom oscillation study. INTERVENTIONS:Lung function measurements at a corrected age of 1 year. MAIN OUTCOME MEASURES: Airways resistance (Raw) and functional residual capacity (FRC(pleth)) measured by whole body plethysmography, specific conductance (sGaw) calculated from Raw and FRC(pleth), and FRC measured by a helium gas dilution technique (FRC(He)). RESULTS: The 42 male infants differed significantly from the 34 female infants in having a lowerbirth weight for gestation, requiring more days of ventilation, and a greater proportion being oxygen dependent at 36 weeks postmenstrual age and discharge. Furthermore, mean Raw and FRC(pleth) were significantly higher and mean sGaw significantly lower. After adjustment for birth and current size differences, the sex differences in FRC(pleth) and sGaw were 15% and 26% respectively and remained significant. CONCLUSION:Lung function at follow up of prematurely born infants is influenced by sex.
RCT Entities:
OBJECTIVE: To test the hypothesis that male compared with female prematurely born infants would have worse lung function at follow up. DESIGN: Prospective follow up study. SETTING: Tertiary neonatal intensive care units PATIENTS: Seventy six infants, mean (SD) gestational age 26.4 (1.5) weeks, from the United Kingdom oscillation study. INTERVENTIONS: Lung function measurements at a corrected age of 1 year. MAIN OUTCOME MEASURES: Airways resistance (Raw) and functional residual capacity (FRC(pleth)) measured by whole body plethysmography, specific conductance (sGaw) calculated from Raw and FRC(pleth), and FRC measured by a helium gas dilution technique (FRC(He)). RESULTS: The 42 male infants differed significantly from the 34 female infants in having a lower birth weight for gestation, requiring more days of ventilation, and a greater proportion being oxygen dependent at 36 weeks postmenstrual age and discharge. Furthermore, mean Raw and FRC(pleth) were significantly higher and mean sGaw significantly lower. After adjustment for birth and current size differences, the sex differences in FRC(pleth) and sGaw were 15% and 26% respectively and remained significant. CONCLUSION: Lung function at follow up of prematurely born infants is influenced by sex.
Authors: S Lum; A F Hoo; C Dezateux; I Goetz; A Wade; L DeRooy; K Costeloe; J Stocks Journal: Am J Respir Crit Care Med Date: 2001-12-01 Impact factor: 21.405
Authors: Alice H Johnson; Janet L Peacock; Anne Greenough; Neil Marlow; Elizabeth S Limb; Louise Marston; Sandra A Calvert Journal: N Engl J Med Date: 2002-08-29 Impact factor: 91.245
Authors: Mark R Thomas; Gerrard F Rafferty; Elizabeth S Limb; Janet L Peacock; Sandra A Calvert; Neil Marlow; Anthony D Milner; Anne Greenough Journal: Am J Respir Crit Care Med Date: 2003-12-23 Impact factor: 21.405
Authors: Mar Janna Dahl; Sydney Bowen; Toshio Aoki; Andrew Rebentisch; Elaine Dawson; Luke Pettet; Haleigh Emerson; Baifeng Yu; Zhengming Wang; Haixia Yang; Chong Zhang; Angela P Presson; Lisa Joss-Moore; Donald M Null; Bradley A Yoder; Kurt H Albertine Journal: Am J Physiol Lung Cell Mol Physiol Date: 2018-09-13 Impact factor: 5.464
Authors: Karen M McDowell; Alan H Jobe; Matthew Fenchel; William D Hardie; Tate Gisslen; Lisa R Young; Claire A Chougnet; Stephanie D Davis; Suhas G Kallapur Journal: Ann Am Thorac Soc Date: 2016-06
Authors: M Inés Klein; Eduardo Bergel; Luz Gibbons; Silvina Coviello; Gabriela Bauer; Alicia Benitez; M Elina Serra; M Florencia Delgado; Guillermina A Melendi; Susana Rodríguez; Steven R Kleeberger; Fernando P Polack Journal: Pediatrics Date: 2008-06 Impact factor: 7.124