PURPOSE: To investigate the MRI characteristics of an intracellular manganese-based contrast agent, EVP 1001-1 (Eagle Vision Pharmaceutical Corp.), in a canine model of myocardial infarction. MATERIALS AND METHODS: Three dogs were imaged 14-37 days following permanent ligation of the left anterior descending coronary artery (LAD). Measurements of the longitudinal relaxation rate R(1) were made prior to EVP 1001-1 administration (20 micromol/kg i.v.) and for one hour thereafter. Triphenyl tetrazolium chloride (TTC) staining was used to document infarction. RESULTS: In normal myocardium, EVP 1001-1 produced a substantial increase in the longitudinal relaxation rate, which remained fairly constant over the postcontrast imaging period (DeltaR1= 1.47 +/- 0.58 sec(-1) (mean +/- SD) at 35 minutes, P < 0.05). In the infarct, the response to EVP 1001-1 was small or negligible (DeltaR1= 0.27 +/- 0.28 sec(-1)). This resulted in a significant postcontrast difference in relaxation rate between normal and infarcted tissue (R1(normal) - R1(infarct) = 1.08 +/- 0.26 sec(-1), P < 0.05). The infarct remained clearly delineated in all animals throughout the steady-state imaging period, and qualitatively matched TTC results. CONCLUSION: The persistent enhancement pattern revealed by MRI following EVP 1001-1 administration may be beneficial for identifying and characterizing myocardial infarction. (c) 2006 Wiley-Liss, Inc.
PURPOSE: To investigate the MRI characteristics of an intracellular manganese-based contrast agent, EVP 1001-1 (Eagle Vision Pharmaceutical Corp.), in a canine model of myocardial infarction. MATERIALS AND METHODS: Three dogs were imaged 14-37 days following permanent ligation of the left anterior descending coronary artery (LAD). Measurements of the longitudinal relaxation rate R(1) were made prior to EVP 1001-1 administration (20 micromol/kg i.v.) and for one hour thereafter. Triphenyl tetrazolium chloride (TTC) staining was used to document infarction. RESULTS: In normal myocardium, EVP 1001-1 produced a substantial increase in the longitudinal relaxation rate, which remained fairly constant over the postcontrast imaging period (DeltaR1= 1.47 +/- 0.58 sec(-1) (mean +/- SD) at 35 minutes, P < 0.05). In the infarct, the response to EVP 1001-1 was small or negligible (DeltaR1= 0.27 +/- 0.28 sec(-1)). This resulted in a significant postcontrast difference in relaxation rate between normal and infarcted tissue (R1(normal) - R1(infarct) = 1.08 +/- 0.26 sec(-1), P < 0.05). The infarct remained clearly delineated in all animals throughout the steady-state imaging period, and qualitatively matched TTC results. CONCLUSION: The persistent enhancement pattern revealed by MRI following EVP 1001-1 administration may be beneficial for identifying and characterizing myocardial infarction. (c) 2006 Wiley-Liss, Inc.
Authors: Rajesh Dash; Jaehoon Chung; Fumiaki Ikeno; Annett Hahn-Windgassen; Yuka Matsuura; Mihoko V Bennett; Jennifer K Lyons; Tomohiko Teramoto; Robert C Robbins; Michael V McConnell; Alan C Yeung; Todd J Brinton; Phillip P Harnish; Phillip C Yang Journal: Circ Cardiovasc Imaging Date: 2011-06-30 Impact factor: 7.792
Authors: Atsushi Tachibana; Michelle R Santoso; Morteza Mahmoudi; Praveen Shukla; Lei Wang; Mihoko Bennett; Andrew B Goldstone; Mouer Wang; Masahiro Fukushi; Antje D Ebert; Y Joseph Woo; Eric Rulifson; Phillip C Yang Journal: Circ Res Date: 2017-07-25 Impact factor: 17.367
Authors: Patrick F Antkowiak; Brian K Stevens; Craig S Nunemaker; Marcia McDuffie; Frederick H Epstein Journal: Diabetes Date: 2012-08-29 Impact factor: 9.461
Authors: Juliano L Fernandes; Pippa Storey; Jose Alvaro da Silva; Gabriel S de Figueiredo; Jose M Kalaf; Otavio R Coelho Journal: J Cardiovasc Magn Reson Date: 2011-01-14 Impact factor: 5.364
Authors: Rajesh Dash; Paul J Kim; Yuka Matsuura; Fumiaki Ikeno; Scott Metzler; Ngan F Huang; Jennifer K Lyons; Patricia K Nguyen; Xiaohu Ge; Cheryl Wong Po Foo; Michael V McConnell; Joseph C Wu; Alan C Yeung; Phillip Harnish; Phillip C Yang Journal: J Am Heart Assoc Date: 2015-07-27 Impact factor: 5.501