Literature DB >> 16415930

Helicobacter pylori phase variation, immune modulation and gastric autoimmunity.

Mathijs Bergman1, Gianfranco Del Prete, Yvette van Kooyk, Ben Appelmelk.   

Abstract

Helicobacter pylori can be regarded as a model pathogen for studying persistent colonization of humans. Phase-variable expression of Lewis blood-group antigens by H. pylori allows this microorganism to modulate the host T-helper-1-cell versus T-helper-2-cell response. We describe a model in which interactions between host lectins and pathogen carbohydrates facilitate asymptomatic persistence of H. pylori. This delicate balance, favourable for both the pathogen and the host, could lead to gastric autoimmunity in genetically susceptible individuals.

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Year:  2006        PMID: 16415930     DOI: 10.1038/nrmicro1344

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN: 1740-1526            Impact factor:   60.633


  33 in total

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6.  Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties.

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Review 8.  Cytotoxic T cells in H. pylori-related gastric autoimmunity and gastric lymphoma.

Authors:  Mathijs P Bergman; Mario M D'Elios
Journal:  J Biomed Biotechnol       Date:  2010-06-22

9.  Helicobacter pylori lipopolysaccharide is synthesized via a novel pathway with an evolutionary connection to protein N-glycosylation.

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Journal:  PLoS Pathog       Date:  2010-03-19       Impact factor: 6.823

Review 10.  Autoimmune atrophic gastritis--pathogenesis, pathology and management.

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