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Literature DB >> 22205825

Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties.

Ramakrishnan Sitaraman¹, Dawn A Israel, Judith Romero-Gallo, Richard M Peek.

Abstract

Pathogenic Helicobacter pylori strains can selectively activate epithelial mitogen-activated protein kinase (MAPK) signaling pathways linked with disease. We now demonstrate that H. pylori-induced hemolysis is strain specific and is mediated by phospholipases PldA1 and PldD. Inactivation of PldD inhibited activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), indicating that H. pylori hemolytic phospholipases also harbor MAPK-activating properties.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22205825 PMCID： PMC3295145 DOI： 10.1128/JCM.05252-11

Source DB: PubMed Journal: J Clin Microbiol ISSN： 0095-1137 Impact factor: 5.948

35 in total

1. Conservation and microdiversity of the phospholipase A (pldA) gene of Helicobacter pylori infecting dyspeptics from different countries.

Authors: J Xerry; R J Owen
Journal: FEMS Immunol Med Microbiol Date: 2001-12

Review 2. Helicobacter pylori and gastrointestinal tract adenocarcinomas.

Authors: Richard M Peek; Martin J Blaser
Journal: Nat Rev Cancer Date: 2002-01 Impact factor: 60.716

3. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses.

Authors: D A Israel; N Salama; C N Arnold; S F Moss; T Ando; H P Wirth; K T Tham; M Camorlinga; M J Blaser; S Falkow; R M Peek
Journal: J Clin Invest Date: 2001-03 Impact factor: 14.808

4. Role of Helicobacter pylori cag region genes in colonization and gastritis in two animal models.

Authors: K A Eaton; D Kersulyte; M Mefford; S J Danon; S Krakowka; D E Berg
Journal: Infect Immun Date: 2001-05 Impact factor: 3.441

5. Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes.

Authors: A V Karlyshev; P C Oyston; K Williams; G C Clark; R W Titball; E A Winzeler; B W Wren
Journal: Infect Immun Date: 2001-12 Impact factor: 3.441

Review 6. Helicobacter pylori virulence factors and the host immune response: implications for therapeutic vaccination.

Authors: Christian Prinz; Nadia Hafsi; Petra Voland
Journal: Trends Microbiol Date: 2003-03 Impact factor: 17.079

Review 7. ExoU is a potent intracellular phospholipase.

Authors: Hiromi Sato; Dara W Frank
Journal: Mol Microbiol Date: 2004-09 Impact factor: 3.501

8. Phospholipases C are involved in the virulence of Mycobacterium tuberculosis.

Authors: Catherine Raynaud; Christophe Guilhot; Jean Rauzier; Yann Bordat; Vladimir Pelicic; Riccardo Manganelli; Issar Smith; Brigitte Gicquel; Mary Jackson
Journal: Mol Microbiol Date: 2002-07 Impact factor: 3.501

9. Sphingomyelinase of Helicobacter pylori-induced cytotoxicity in AGS gastric epithelial cells via activation of JNK kinase.

Authors: Hong-Jia Tseng; Chung-Chuan Chan; Err-Cheng Chan
Journal: Biochem Biophys Res Commun Date: 2004-02-06 Impact factor: 3.575

Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties.

1. Conservation and microdiversity of the phospholipase A (pldA) gene of Helicobacter pylori infecting dyspeptics from different countries.

Review 2. Helicobacter pylori and gastrointestinal tract adenocarcinomas.

3. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses.

4. Role of Helicobacter pylori cag region genes in colonization and gastritis in two animal models.

5. Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes.

Review 6. Helicobacter pylori virulence factors and the host immune response: implications for therapeutic vaccination.

Review 7. ExoU is a potent intracellular phospholipase.

8. Phospholipases C are involved in the virulence of Mycobacterium tuberculosis.

9. Sphingomyelinase of Helicobacter pylori-induced cytotoxicity in AGS gastric epithelial cells via activation of JNK kinase.

10. Activation of syndecan-1 ectodomain shedding by Staphylococcus aureus alpha-toxin and beta-toxin.

1. Phospholipid catabolism by gut microbiota and the risk of cardiovascular disease.

Review 2. Bacterial Sphingomyelinases and Phospholipases as Virulence Factors.

Review 3. Helicobacter pylori Virulence Factors-Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment.

Review 4. Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms.