| Literature DB >> 16413479 |
Abstract
The small protein ubiquitin is often linked to substrates as a polymer. Such polymers vary in both linkage and length, which has important consequences for their function. Surprisingly, the mechanisms of ubiquitin-chain assembly are still not known. Deciphering them will shed light on why substrates differ in the extent and timing of polyubiquitin modification and how ancillary ubiquitination factors function.Entities:
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Year: 2006 PMID： 16413479 DOI： 10.1016/j.cell.2005.12.025
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582