Literature DB >> 16412567

Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J2 through the downregulation of angiopoietin-1.

Yuan-Gen Fu1, Joseph J Y Sung, Kai-Chun Wu, Alfa H C Bai, Martin C W Chan, Jun Yu, Dai-Ming Fan, Wai K Leung.   

Abstract

Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have been shown to inhibit angiogenesis. We showed that treatment with 15d-PGJ(2), a PPARgamma ligand, downregulate the expressions of angiopoietin-1 (Ang-1) in gastric cancer cells MKN45. The medium of MKN45 cells treated with 15d-PGJ(2) significantly inhibited the migration and tube formation of human umbilical vein endothelial cells (HUVECs). Moreover, Matrigel plug assay revealed that 15d-PGJ(2) reduced in vivo angiogenesis induced by MKN45 cells. These modulations were restored by the addition of recombinant Ang-1. Our findings supported that 15d-PGJ(2) suppressed angiogenesis of gastric cancer cells by downregulation of Ang-1.

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Year:  2006        PMID： 16412567     DOI： 10.1016/j.canlet.2005.11.039

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

1.  Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy.

Authors:  Anne R Diers; Brian P Dranka; Karina C Ricart; Joo Yeun Oh; Michelle S Johnson; Fen Zhou; Manuel A Pallero; Thomas M Bodenstine; Joanne E Murphy-Ullrich; Danny R Welch; Aimee Landar
Journal:  Biochem J       Date:  2010-08-15       Impact factor: 3.857

Review 2.  H2S and its role in redox signaling.

Authors:  Omer Kabil; Nicole Motl; Ruma Banerjee
Journal:  Biochim Biophys Acta       Date:  2014-01-11

Review 3.  Sulfur as a signaling nutrient through hydrogen sulfide.

Authors:  Omer Kabil; Victor Vitvitsky; Ruma Banerjee
Journal:  Annu Rev Nutr       Date:  2014       Impact factor: 11.848

4.  Angiopoietin-1 targeted RNA interference suppresses angiogenesis and tumor growth of esophageal cancer.

Authors:  Xiao-Hong Liu; Chen-Guang Bai; Yang Yuan; De-Jun Gong; Sheng-Dong Huang
Journal:  World J Gastroenterol       Date:  2008-03-14       Impact factor: 5.742

Review 5.  15d-PGJ2 is a new hope for controlling tumor growth.

Authors:  Qingli Bie; Haixin Dong; Chengqiang Jin; Hao Zhang; Bin Zhang
Journal:  Am J Transl Res       Date:  2018-03-15       Impact factor: 4.060

6.  PPAR Ligands as Potential Modifiers of Breast Carcinoma Outcomes.

Authors:  Ancha Baranova
Journal:  PPAR Res       Date:  2008       Impact factor: 4.964

7.  Peroxisome Proliferator-Activated Receptor-gamma Ligands: Potential Pharmacological Agents for Targeting the Angiogenesis Signaling Cascade in Cancer.

Authors:  Costas Giaginis; Anna Tsantili-Kakoulidou; Stamatios Theocharis
Journal:  PPAR Res       Date:  2008       Impact factor: 4.964

8.  PPARgamma and Agonists against Cancer: Rational Design of Complementation Treatments.

Authors:  Dorina Veliceasa; Frank Thilo Schulze-Hoëpfner; Olga V Volpert
Journal:  PPAR Res       Date:  2008-11-18       Impact factor: 4.964

Review 9.  PPARgamma activation by thiazolidinediones (TZDs) may modulate breast carcinoma outcome: the importance of interplay with TGFbeta signalling.

Authors:  Mohammed H Jarrar; Ancha Baranova
Journal:  J Cell Mol Med       Date:  2007 Jan-Feb       Impact factor: 5.310

Review 10.  Cyclopentenone Prostaglandins: Biologically Active Lipid Mediators Targeting Inflammation.

Authors:  Bohae Rachel Lee; May Hnin Paing; Neelam Sharma-Walia
Journal:  Front Physiol       Date:  2021-07-15       Impact factor: 4.566
  10 in total

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