Literature DB >> 29636856

15d-PGJ2 is a new hope for controlling tumor growth.

Qingli Bie1,2, Haixin Dong1, Chengqiang Jin1, Hao Zhang1,3, Bin Zhang1,2.   

Abstract

15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a natural PPARγ agonist, has been investigated for over a decade. Studies have revealed that it has proapoptotic, anti-inflammatory, antiangiogenic, and anti-metastatic abilities, as well as a significant anticancer effect. However, the mechanisms underlying the actions of 15d-PGJ2 on various tumors are only partially known. In this review, we discuss the recent progress in elucidating these mechanisms. Understanding the various functions and mechanisms of 15d-PGJ2 are crucial for the development of new therapies for controlling tumor growth and providing the basis for further research.

Entities:  

Keywords:  15d-PGJ2; Prostaglandins; angiogenesis; anti-inflammatory; apoptosis; metastasis

Year:  2018        PMID： 29636856      PMCID： PMC5883107     

Source DB:  PubMed          Journal:  Am J Transl Res        ISSN： 1943-8141            Impact factor:   4.060


  98 in total

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Journal:  J Mammary Gland Biol Neoplasia       Date:  1999-10       Impact factor: 2.673

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4.  Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death.

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Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

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Journal:  J Biol Chem       Date:  1999-06-11       Impact factor: 5.157

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Journal:  J Biol Chem       Date:  1999-03-26       Impact factor: 5.157

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Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

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  7 in total

Review 1.  The p38/MKP-1 signaling axis in oral cancer: Impact of tumor-associated macrophages.

Authors:  Zhenning Li; Fa-Yu Liu; Keith L Kirkwood
Journal:  Oral Oncol       Date:  2020-02-10       Impact factor: 5.337

2.  Sustained exposure to prostaglandin D2 augments the contraction induced by acetylcholine via a DP1 receptor-mediated activation of p38 in bronchial smooth muscle of naive mice.

Authors:  Wataru Suto; Hiroyasu Sakai; Yoshihiko Chiba
Journal:  J Smooth Muscle Res       Date:  2019

3.  15d-PGJ2 Promotes ROS-Dependent Activation of MAPK-Induced Early Apoptosis in Osteosarcoma Cell In Vitro and in an Ex Ovo CAM Assay.

Authors:  Mateja Mikulčić; Nassim Ghaffari Tabrizi-Wizsy; Eva M Bernhart; Martin Asslaber; Christopher Trummer; Werner Windischhofer; Wolfgang Sattler; Ernst Malle; Andelko Hrzenjak
Journal:  Int J Mol Sci       Date:  2021-10-29       Impact factor: 5.923

4.  YAP promotes self-renewal of gastric cancer cells by inhibiting expression of L-PTGDS and PTGDR2.

Authors:  Qingli Bie; Xiaozhe Li; Shiqi Liu; Xiao Yang; Zhenwen Qian; Rou Zhao; Xiaobei Zhang; Bin Zhang
Journal:  Int J Clin Oncol       Date:  2020-08-26       Impact factor: 3.402

Review 5.  Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics.

Authors:  Ainsley Mike Antao; Apoorvi Tyagi; Kye-Seong Kim; Suresh Ramakrishna
Journal:  Cancers (Basel)       Date:  2020-06-15       Impact factor: 6.639

6.  15-Deoxy-Δ12,14-prostaglandin J2 Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells.

Authors:  Jong-Min Park; Hye-Kyung Na
Journal:  J Cancer Prev       Date:  2019-09-30

7.  Clostridium butyricum Modulates the Microbiome to Protect Intestinal Barrier Function in Mice with Antibiotic-Induced Dysbiosis.

Authors:  Mao Hagihara; Yasutoshi Kuroki; Tadashi Ariyoshi; Seiya Higashi; Kazuo Fukuda; Rieko Yamashita; Asami Matsumoto; Takeshi Mori; Kaoru Mimura; Naoko Yamaguchi; Shoshiro Okada; Tsunemasa Nonogaki; Tadashi Ogawa; Kenta Iwasaki; Susumu Tomono; Nobuhiro Asai; Yusuke Koizumi; Kentaro Oka; Yuka Yamagishi; Motomichi Takahashi; Hiroshige Mikamo
Journal:  iScience       Date:  2019-12-13
  7 in total

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