Literature DB >> 16407123

TAF7: a possible transcription initiation check-point regulator.

Anne Gegonne1, Jocelyn D Weissman, Meisheng Zhou, John N Brady, Dinah S Singer.   

Abstract

Transcription consists of a series of highly regulated steps: assembly of a preinitiation complex (PIC) at the promoter nucleated by TFIID, followed by initiation, elongation, and termination. The present study has focused on the role of the TFIID component, TAF7, in regulating transcription initiation. In TFIID, TAF7 binds to TAF1 and inhibits its intrinsic acetyl transferase activity. We now report that although TAF7 remains bound to TAF1 and associated with TFIID during the formation of the PIC, TAF7 dissociates from the PIC upon transcription initiation. Entry of polymerase II into the assembling PIC is associated with TAF1 and TAF7 phosphorylation, coincident with TAF7 release. We propose that the TFIID composition is dynamic and that TAF7 functions as a check-point regulator suppressing premature transcription initiation until PIC assembly is complete.

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Year:  2006        PMID： 16407123      PMCID： PMC1325967          DOI： 10.1073/pnas.0510031103

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  41 in total

Review 1.  Investigating RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation.

Authors:  Benoît Palancade; Olivier Bensaude
Journal:  Eur J Biochem       Date:  2003-10

Review 2.  Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression.

Authors:  Andreas Hochheimer; Robert Tjian
Journal:  Genes Dev       Date:  2003-06-01       Impact factor: 11.361

3.  Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly.

Authors:  Wu-Cheng Shen; Sukesh R Bhaumik; Helen C Causton; Itamar Simon; Xiaochun Zhu; Ezra G Jennings; Tseng-Hsing Wang; Richard A Young; Michael R Green
Journal:  EMBO J       Date:  2003-07-01       Impact factor: 11.598

Review 4.  Structure and mechanism of the RNA polymerase II transcription machinery.

Authors:  Steven Hahn
Journal:  Nat Struct Mol Biol       Date:  2004-05       Impact factor: 15.369

5.  A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiae.

Authors:  Kathryn L Huisinga; B Franklin Pugh
Journal:  Mol Cell       Date:  2004-02-27       Impact factor: 17.970

6.  Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo.

Authors:  Brian E Schwartz; Stephane Larochelle; Beat Suter; John T Lis
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

7.  Distinct transcriptional pathways regulate basal and activated major histocompatibility complex class I expression.

Authors:  T Kevin Howcroft; Aparna Raval; Jocelyn D Weissman; Anne Gegonne; Dinah S Singer
Journal:  Mol Cell Biol       Date:  2003-05       Impact factor: 4.272

8.  Transcription factor and polymerase recruitment, modification, and movement on dhsp70 in vivo in the minutes following heat shock.

Authors:  Amber K Boehm; Abbie Saunders; Janis Werner; John T Lis
Journal:  Mol Cell Biol       Date:  2003-11       Impact factor: 4.272

9.  DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.

Authors:  Christopher J Bakkenist; Michael B Kastan
Journal:  Nature       Date:  2003-01-30       Impact factor: 49.962

10.  Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex.

Authors:  N Tanese; B F Pugh; R Tjian
Journal:  Genes Dev       Date:  1991-12       Impact factor: 11.361
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  24 in total

1.  The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells.

Authors:  Anne Gegonne; Xuguang Tai; Jinghui Zhang; Gang Wu; Jianjian Zhu; Aki Yoshimoto; Jeffrey Hanson; Constance Cultraro; Qing-Rong Chen; Terry Guinter; Zhihui Yang; Karen Hathcock; Alfred Singer; Jaime Rodriguez-Canales; Lino Tessarollo; Susan Mackem; Daoud Meerzaman; Ken Buetow; Dinah S Singer
Journal:  Mol Cell Biol       Date:  2012-03-12       Impact factor: 4.272

2.  Novel functions for TAF7, a regulator of TAF1-independent transcription.

Authors:  Ballachanda N Devaiah; Hanxin Lu; Anne Gegonne; Zeynep Sercan; Hongen Zhang; Robert J Clifford; Maxwell P Lee; Dinah S Singer
Journal:  J Biol Chem       Date:  2010-10-11       Impact factor: 5.157

3.  Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells.

Authors:  Anniina Vihervaara; Christian Sergelius; Jenni Vasara; Malin A H Blom; Alexandra N Elsing; Pia Roos-Mattjus; Lea Sistonen
Journal:  Proc Natl Acad Sci U S A       Date:  2013-08-19       Impact factor: 11.205

4.  Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation.

Authors:  Ballachanda N Devaiah; Dinah S Singer
Journal:  J Biol Chem       Date:  2012-10-01       Impact factor: 5.157

Review 5.  TAF7: traffic controller in transcription initiation.

Authors:  Anne Gegonne; Ballachanda N Devaiah; Dinah S Singer
Journal:  Transcription       Date:  2013 Jan-Feb

6.  Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D.

Authors:  Suparna Bhattacharya; Xiaohua Lou; Peter Hwang; Kanagalaghatta R Rajashankar; Xiaoping Wang; Jan-Åke Gustafsson; Robert J Fletterick; Raymond H Jacobson; Paul Webb
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-10       Impact factor: 11.205

Review 7.  Unique aspects of transcription regulation in male germ cells.

Authors:  Helen White-Cooper; Irwin Davidson
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-07-01       Impact factor: 10.005

8.  Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.

Authors:  Susan L Kloet; Jennifer L Whiting; Phil Gafken; Jeff Ranish; Edith H Wang
Journal:  Mol Cell Biol       Date:  2012-06-18       Impact factor: 4.272

9.  Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters.

Authors:  Kazushige Ohtsuki; Koji Kasahara; Katsuhiko Shirahige; Tetsuro Kokubo
Journal:  Nucleic Acids Res       Date:  2009-12-21       Impact factor: 16.971

10.  Transcriptional coactivator CIITA, a functional homolog of TAF1, has kinase activity.

Authors:  Katherine C Soe; Ballachanda N Devaiah; Dinah S Singer
Journal:  Biochim Biophys Acta       Date:  2013-09-13
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