OBJECTIVE: Functional connectivity maps the distributed network of brain regions fluctuating synchronously during a continuous brain state. This study sought to investigate whether patients with left temporal lobe epilepsy (TLE) differ from controls in their resting-state functional connectivity between typical language regions. METHODS: We studied 17 patients with left TLE, together with eight healthy controls, using seeded functional connectivity. Seed regions were defined using the regions of maximal activation and deactivation during a language functional magnetic resonance imaging (fMRI) task in a separate cohort of 30 controls. RESULTS: Language fMRI produced the expected activation pattern, which was not different between patients and controls. However, functional connectivity between language areas during rest was markedly different; whereas controls showed connectivity between each of the seed areas and the majority of the language areas, patients showed connectivity only with a few areas, particularly the seed area itself. This difference was significant in the direct comparison of patients and control connectivity maps. INTERPRETATION: We suggest that this reduced connectivity in left temporal lobe epilepsy may reflect a disturbance of the language network during resting state in patients and may be related to subtle language difficulties in this patient population.
OBJECTIVE: Functional connectivity maps the distributed network of brain regions fluctuating synchronously during a continuous brain state. This study sought to investigate whether patients with left temporal lobe epilepsy (TLE) differ from controls in their resting-state functional connectivity between typical language regions. METHODS: We studied 17 patients with left TLE, together with eight healthy controls, using seeded functional connectivity. Seed regions were defined using the regions of maximal activation and deactivation during a language functional magnetic resonance imaging (fMRI) task in a separate cohort of 30 controls. RESULTS: Language fMRI produced the expected activation pattern, which was not different between patients and controls. However, functional connectivity between language areas during rest was markedly different; whereas controls showed connectivity between each of the seed areas and the majority of the language areas, patients showed connectivity only with a few areas, particularly the seed area itself. This difference was significant in the direct comparison of patients and control connectivity maps. INTERPRETATION: We suggest that this reduced connectivity in left temporal lobe epilepsy may reflect a disturbance of the language network during resting state in patients and may be related to subtle language difficulties in this patient population.
Authors: Gaëlle Doucet; Karol Osipowicz; Ashwini Sharan; Michael R Sperling; Joseph I Tracy Journal: Hum Brain Mapp Date: 2012-04-16 Impact factor: 5.038
Authors: Fabrício R S Pereira; Andréa Alessio; Maurício S Sercheli; Tatiane Pedro; Elizabeth Bilevicius; Jane M Rondina; Helka F B Ozelo; Gabriela Castellano; Roberto J M Covolan; Benito P Damasceno; Fernando Cendes Journal: BMC Neurosci Date: 2010-06-02 Impact factor: 3.288
Authors: Brendan D Killory; Xiaoxiao Bai; Michiro Negishi; Clemente Vega; Marisa N Spann; Matthew Vestal; Jennifer Guo; Rachel Berman; Nathan Danielson; Jerry Trejo; David Shisler; Edward J Novotny; R Todd Constable; Hal Blumenfeld Journal: Neuroimage Date: 2011-03-21 Impact factor: 6.556