Literature DB >> 22003908

Prospects for imaging-related biomarkers of human epileptogenesis: a critical review.

William A Gomes1, Shlomo Shinnar.   

Abstract

To facilitate the study of epileptogenesis in humans, noninvasive biomarkers of epileptogenesis are required. No validated biomarker is currently available, but brain imaging techniques provide many attractive candidates. In this article we examine the imaging features of temporal lobe epilepsy, focusing on those that may precede the onset of epilepsy and correlate with epileptogenesis. Hippocampal volumetry and T(2) relaxometry are proposed as candidate biomarkers of epileptogenesis in temporal lobe epilepsy following febrile status epilepticus. Preliminary data suggest that these have promise, and the ongoing Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) study will provide more conclusive evidence as to their validity. At this time there are no other clear candidates for imaging-related biomarkers of epileptogenesis in human studies.

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Year:  2011        PMID： 22003908      PMCID： PMC3235417          DOI： 10.2217/bmm.11.66

Source DB:  PubMed          Journal:  Biomark Med        ISSN： 1752-0363            Impact factor:   2.851


  44 in total

1.  Febrile Seizures and Mesial Temporal Sclerosis.

Authors:  Shlomo Shinnar
Journal:  Epilepsy Curr       Date:  2003-07       Impact factor: 7.500

2.  Hippocampal MRI signal hyperintensity after febrile status epilepticus is predictive of subsequent mesial temporal sclerosis.

Authors:  James M Provenzale; Daniel P Barboriak; Kevan VanLandingham; James MacFall; David Delong; Darrell V Lewis
Journal:  AJR Am J Roentgenol       Date:  2008-04       Impact factor: 3.959

3.  Prognostic significance of tuber count and location in tuberous sclerosis complex.

Authors:  Colin Doherty; Suzanne Goh; Tina Young Poussaint; Namik Erdag; Elizabeth A Thiele
Journal:  J Child Neurol       Date:  2005-10       Impact factor: 1.987

4.  Does acquired epileptogenesis in the immature brain require neuronal death.

Authors:  Tallie Z Baram; Frances E Jensen; Amy Brooks-Kayal
Journal:  Epilepsy Curr       Date:  2011-01       Impact factor: 7.500

5.  Quantitative neuropathology and quantitative magnetic resonance imaging of the hippocampus in temporal lobe epilepsy.

Authors:  W Van Paesschen; T Revesz; J S Duncan; M D King; A Connelly
Journal:  Ann Neurol       Date:  1997-11       Impact factor: 10.422

6.  Epilepsy syndromes in patients with childhood-onset seizures in Finland.

Authors:  M Sillanpää; M Jalava; S Shinnar
Journal:  Pediatr Neurol       Date:  1999-08       Impact factor: 3.372

Review 7.  Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions.

Authors:  Darrell V Lewis; Daniel P Barboriak; James R MacFall; James M Provenzale; Teresa V Mitchell; Kevan E VanLandingham
Journal:  Prog Brain Res       Date:  2002       Impact factor: 2.453

8.  Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination.

Authors:  J A French; P D Williamson; V M Thadani; T M Darcey; R H Mattson; S S Spencer; D D Spencer
Journal:  Ann Neurol       Date:  1993-12       Impact factor: 10.422

9.  Spectroscopic imaging of the pilocarpine model of human epilepsy suggests that early NAA reduction predicts epilepsy.

Authors:  W A Gomes; F A Lado; N C de Lanerolle; K Takahashi; C Pan; H P Hetherington
Journal:  Magn Reson Med       Date:  2007-08       Impact factor: 4.668

10.  Seizure-associated hippocampal volume loss: a longitudinal magnetic resonance study of temporal lobe epilepsy.

Authors:  Regula S Briellmann; Samuel F Berkovic; Ari Syngeniotis; Mark A King; Graeme D Jackson
Journal:  Ann Neurol       Date:  2002-05       Impact factor: 10.422
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  16 in total

1.  In search of epilepsy biomarkers in the immature brain: goals, challenges and strategies.

Authors:  Aristea S Galanopoulou; Solomon L Moshé
Journal:  Biomark Med       Date:  2011-10       Impact factor: 2.851

Review 2.  The challenge and promise of anti-epileptic therapy development in animal models.

Authors:  Michele Simonato; Amy R Brooks-Kayal; Jerome Engel; Aristea S Galanopoulou; Frances E Jensen; Solomon L Moshé; Terence J O'Brien; Asla Pitkanen; Karen S Wilcox; Jacqueline A French
Journal:  Lancet Neurol       Date:  2014-08-10       Impact factor: 44.182

3.  Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study.

Authors:  Darrell V Lewis; Shlomo Shinnar; Dale C Hesdorffer; Emilia Bagiella; Jacqueline A Bello; Stephen Chan; Yuan Xu; James MacFall; William A Gomes; Solomon L Moshé; Gary W Mathern; John M Pellock; Douglas R Nordli; L Matthew Frank; James Provenzale; Ruth C Shinnar; Leon G Epstein; David Masur; Claire Litherland; Shumei Sun
Journal:  Ann Neurol       Date:  2014-03-01       Impact factor: 10.422

Review 4.  Neuroimaging the epileptogenic process.

Authors:  Sandy R Shultz; Terence J O'Brien; Maria Stefanidou; Ruben I Kuzniecky
Journal:  Neurotherapeutics       Date:  2014-04       Impact factor: 7.620

5.  From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate.

Authors:  Brad A Hobson; Sílvia Sisó; Douglas J Rowland; Danielle J Harvey; Donald A Bruun; Joel R Garbow; Pamela J Lein
Journal:  Toxicol Sci       Date:  2017-06-01       Impact factor: 4.849

Review 6.  Biomarkers for epileptogenesis and its treatment.

Authors:  Jerome Engel; Asla Pitkänen
Journal:  Neuropharmacology       Date:  2019-08-01       Impact factor: 5.250

Review 7.  Update on Cysticercosis Epileptogenesis: the Role of the Hippocampus.

Authors:  Oscar H Del Brutto; Jerome Engel; Dawn S Eliashiv; Hector H García
Journal:  Curr Neurol Neurosci Rep       Date:  2016-01       Impact factor: 5.081

8.  Design and phenomenology of the FEBSTAT study.

Authors:  Dale C Hesdorffer; Shlomo Shinnar; Darrell V Lewis; Solomon L Moshé; Douglas R Nordli; John M Pellock; James MacFall; Ruth C Shinnar; David Masur; L Matthew Frank; Leon G Epstein; Claire Litherland; Syndi Seinfeld; Jacqueline A Bello; Stephen Chan; Emilia Bagiella; Shumei Sun
Journal:  Epilepsia       Date:  2012-06-28       Impact factor: 5.864

Review 9.  Anti-epileptogenic clinical trial designs in epilepsy: issues and options.

Authors:  Dieter Schmidt; Daniel Friedman; Marc A Dichter
Journal:  Neurotherapeutics       Date:  2014-04       Impact factor: 7.620

Review 10.  Status Epilepticus.

Authors:  Syndi Seinfeld; Howard P Goodkin; Shlomo Shinnar
Journal:  Cold Spring Harb Perspect Med       Date:  2016-03-01       Impact factor: 6.915
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