| Literature DB >> 16403640 |
Yan Liu1, Yufang Xu, Xuhong Qian, Jianwen Liu, Liyun Shen, Junhui Li, Yuanxing Zhang.
Abstract
Novel naphthalimides with two heterocyclic side chains of 2-nitroimidazole for bioreductive binding were designed, synthesized, and used as fluorescent markers for hypoxic cells. Their evaluation for imaging tumor hypoxia was carried out in V79 cells, CHO cells, and 95D cells in vitro by using fluorescence scan ascent. A2 and A4 showed a very large differential fluorescence between hypoxic and oxic cells (V79 cells) in vitro and are promising candidate markers for hypoxic cells.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16403640 DOI： 10.1016/j.bmc.2005.12.012
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641