Literature DB >> 22347839

Molecular Imaging of Hypoxia: Strategies for Probe Design and Application.

Sandeep Apte1, Frederick T Chin, Edward E Graves.   

Abstract

Tumor hypoxia is a negative prognostic factor and its precise imaging is of great relevance to therapy planning. The present review summarizes various strategies of probe design for imaging hypoxia with a variety of techniques such as PET, SPECT and fluorescence imaging. Synthesis of some important probes that are used for preclinical and clinical imaging and their mechanism of binding in hypoxia are also discussed.

Entities:  

Year:  2011        PMID： 22347839      PMCID： PMC3279754          DOI： 10.2174/157017911796117179

Source DB:  PubMed          Journal:  Curr Org Synth        ISSN： 1570-1794            Impact factor:   1.975


  72 in total

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Review 2.  Exploiting tumour hypoxia in cancer treatment.

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Journal:  Radiother Oncol       Date:  1998-03       Impact factor: 6.280

5.  Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker.

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Journal:  Cancer Res       Date:  1998-09-01       Impact factor: 12.701

6.  Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: retrospective study in a series of 745 patients.

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Journal:  Int J Cancer       Date:  2005-09-20       Impact factor: 7.396

7.  131 I-cG250 monoclonal antibody immunoscintigraphy versus [18 F]FDG-PET imaging in patients with metastatic renal cell carcinoma: a comparative study.

Authors:  A H Brouwers; U Dorr; O Lang; O C Boerman; W J G Oyen; M G Steffens; E Oosterwijk; H G Mergenthaler; H Bihl; F H M Corstens
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8.  Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

Authors:  D M Brizel; S P Scully; J M Harrelson; L J Layfield; J M Bean; L R Prosnitz; M W Dewhirst
Journal:  Cancer Res       Date:  1996-03-01       Impact factor: 12.701

9.  2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors.

Authors:  S M Evans; W T Jenkins; B Joiner; E M Lord; C J Koch
Journal:  Cancer Res       Date:  1996-01-15       Impact factor: 12.701

10.  Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET.

Authors:  Emmanuelle Briard; Sami S Zoghbi; Fabrice G Siméon; Masao Imaizumi; Jonathan P Gourley; H Umesha Shetty; Shuiyu Lu; Masahiro Fujita; Robert B Innis; Victor W Pike
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  6 in total

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Authors:  Raghu Erapaneedi; Vsevolod V Belousov; Michael Schäfers; Friedemann Kiefer
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2.  Imaging latent tuberculosis infection with radiolabeled nitroimidazoles.

Authors:  Alfred O Ankrah; Andor W J M Glaudemans; Mike M Sathekge; Hans C Klein
Journal:  Clin Transl Imaging       Date:  2016-03-22

3.  Azo-Based Iridium(III) Complexes as Multicolor Phosphorescent Probes to Detect Hypoxia in 3D Multicellular Tumor Spheroids.

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4.  An Activatable Near-Infrared Chromophore for Multispectral Optoacoustic Imaging of Tumor Hypoxia and for Tumor Inhibition.

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Journal:  Theranostics       Date:  2019-09-25       Impact factor: 11.556

5.  A NIR fluorescent smart probe for imaging tumor hypoxia.

Authors:  Kenneth S Hettie; Jessica L Klockow; Eui Jung Moon; Amato J Giaccia; Frederick T Chin
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6.  Transcatheter arterial embolization promotes liver tumor metastasis by increasing the population of circulating tumor cells.

Authors:  Zhu-Ting Fang; Guang-Zhi Wang; Wei Zhang; Xu-Dong Qu; Rong Liu; Sheng Qian; Liang Zhu; Bo Zhou; Jian-Hua Wang
Journal:  Onco Targets Ther       Date:  2013-11-05       Impact factor: 4.147
  6 in total

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