Literature DB >> 16397527

A PANorama of PAX genes in cancer and development.

Ewan J D Robson1, Shu-Jie He, Michael R Eccles.   

Abstract

Populations of self-renewing cells that arise during normal embryonic development harbour the potential for rapid proliferation, migration or transdifferentiation and, therefore, tumour generation. So, control mechanisms are essential to prevent rapidly expanding populations from malignant growth. Transcription factors have crucial roles in ensuring establishment of such regulation, with the Pax gene family prominent amongst these. This review examines the role of Pax family members during embryogenesis, and their contribution to tumorigenesis when subverted.

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Year:  2006        PMID： 16397527     DOI： 10.1038/nrc1778

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  103 in total

1.  Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.

Authors:  Sanjeevkumar R Patel; Samina S Bhumbra; Raghavendra S Paknikar; Gregory R Dressler
Journal:  Mol Cell       Date:  2011-12-08       Impact factor: 17.970

2.  Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crest.

Authors:  Sarah C Morgan; Hyung-Yul Lee; Frédéric Relaix; Lisa L Sandell; John M Levorse; Mary R Loeken
Journal:  Mech Dev       Date:  2008-07-13       Impact factor: 1.882

3.  Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome.

Authors:  Terence D Capellini; Rediet Zewdu; Giuseppina Di Giacomo; Stefania Asciutti; Jamie E Kugler; Anna Di Gregorio; Licia Selleri
Journal:  Dev Biol       Date:  2008-04-16       Impact factor: 3.582

4.  The evolution of alternative splicing in the Pax family: the view from the Basal chordate amphioxus.

Authors:  Stephen Short; Linda Z Holland
Journal:  J Mol Evol       Date:  2008-05-14       Impact factor: 2.395

5.  The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis.

Authors:  Mihoko Kato; Paul W Sternberg
Journal:  Development       Date:  2009-12       Impact factor: 6.868

Review 6.  Polycomb group proteins: navigators of lineage pathways led astray in cancer.

Authors:  Adrian P Bracken; Kristian Helin
Journal:  Nat Rev Cancer       Date:  2009-11       Impact factor: 60.716

Review 7.  Pax-8-PPAR-γ fusion protein in thyroid carcinoma.

Authors:  Priyadarshini Raman; Ronald J Koenig
Journal:  Nat Rev Endocrinol       Date:  2014-07-29       Impact factor: 43.330

8.  Homeobox Gene Deregulation: Impact on the Hallmarks of Cancer.

Authors:  Dhwani Haria; Honami Naora
Journal:  Cancer Hallm       Date:  2013-09-01

9.  Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group.

Authors:  Elai Davicioni; Michael J Anderson; Friedrich Graf Finckenstein; James C Lynch; Stephen J Qualman; Hiroyuki Shimada; Deborah E Schofield; Jonathan D Buckley; William H Meyer; Poul H B Sorensen; Timothy J Triche
Journal:  Am J Pathol       Date:  2009-01-15       Impact factor: 4.307

10.  SUMOylation of Pax7 is essential for neural crest and muscle development.

Authors:  Zhidong Luan; Ying Liu; Timothy J Stuhlmiller; Jonathan Marquez; Martín I García-Castro
Journal:  Cell Mol Life Sci       Date:  2012-12-18       Impact factor: 9.261
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