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Literature DB >> 16392666

Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.

Rui Liu¹, Cheng-Bin Cui, Lin Duan, Qian-Qun Gu, Wei-Ming Zhu.

Abstract

Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs--metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.

Entities: Chemical Disease Species

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Year: 2005 PMID： 16392666 DOI： 10.1007/BF02977899

Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946

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Cited

21 in total

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2. Research on marine actinobacteria in India.

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3. Enhancement of undecylprodigiosin production from marine endophytic recombinant strain Streptomyces sp. ALAA-R20 through low-cost induction strategy.

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Journal: J Appl Genet Date: 2021-01-07 Impact factor: 3.240

4. The complete genomic sequence of Streptomyces spectabilis NRRL-2792 and identification of secondary metabolite biosynthetic gene clusters.

Authors: Arkadeep Sinha; Silvia Phillips-Salemka; Tanu-Adhikari Niraula; Kevin A Short; Narayan P Niraula
Journal: J Ind Microbiol Biotechnol Date: 2019-06-13 Impact factor: 3.346

Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.

Review 1. Microbial pigments as natural color sources: current trends and future perspectives.

2. Research on marine actinobacteria in India.

3. Enhancement of undecylprodigiosin production from marine endophytic recombinant strain Streptomyces sp. ALAA-R20 through low-cost induction strategy.

4. The complete genomic sequence of Streptomyces spectabilis NRRL-2792 and identification of secondary metabolite biosynthetic gene clusters.

5. Cytotoxic Effect of Prodigiosin, Natural Red Pigment, Isolated from Serratia marcescens UFPEDA 398.

6. Mitigation of ROS insults by Streptomyces secondary metabolites in primary cortical neurons.

Review 7. Advances in marine microbial symbionts in the china sea and related pharmaceutical metabolites.

Review 8. Antitumor compounds from marine actinomycetes.

Review 9. Synthesis of the marine pyrroloiminoquinone alkaloids, discorhabdins.

Review 10. Marine drugs from sponge-microbe association--a review.