Literature DB >> 1639174

Deficiency of fibrinolytic enzyme activities in the serum of patients with Alzheimer-type dementia.

T Aoyagi1, T Wada, F Kojima, M Nagai, S Harada, T Takeuchi, K Isse, M Ogura, M Hamamoto, K Tanaka.   

Abstract

Previously we reported that there is a kallikrein deficiency in the cerebral tissue of patients with Alzheimer-type dementia. The present study was performed to investigate protease changes in the serum of these patients. The results showed that the kallikrein activity was normal, but that the activities of plasmin and urokinase were significantly low. The present findings indicate a derangement in the clotting and fibrinolytic systems in Alzheimer patients.

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Year:  1992        PMID： 1639174     DOI： 10.1007/bf02118312

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  25 in total

1.  Stimulated platelets release amyloid beta-protein precursor.

Authors:  G M Cole; D Galasko; I P Shapiro; T Saitoh
Journal:  Biochem Biophys Res Commun       Date:  1990-07-16       Impact factor: 3.575

2.  Upregulation of a lymphoid serine protease in kidney allograft recipients.

Authors:  G Sunder-Plassmann; L Wagner; K Hruby; P Balcke; C P Worman
Journal:  Kidney Int       Date:  1990-05       Impact factor: 10.612

3.  Purification and properties of glycylprolyl -naphthylamidase in human submaxillary gland.

Authors:  H Oya; I Nagatsu; T Nagatsu
Journal:  Biochim Biophys Acta       Date:  1972-02-28

4.  Deficient repair of DNA lesions in Alzheimer's disease fibroblasts.

Authors:  J C Li; E Kaminskas
Journal:  Biochem Biophys Res Commun       Date:  1985-06-28       Impact factor: 3.575

5.  Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with Alzheimer's disease.

Authors:  T Aoyagi; T Wada; M Nagai; F Kojima; S Harada; T Takeuchi; H Takahashi; K Hirokawa; T Tsumita
Journal:  Experientia       Date:  1990-01-15

6.  A rapid assay for dipeptidyl aminopeptidase III in human erythrocytes.

Authors:  T H Jones; A Kapralou
Journal:  Anal Biochem       Date:  1982-01-15       Impact factor: 3.365

7.  Human plasma kallikrein. A rapid purification method with high yield.

Authors:  H Nagase; A J Barrett
Journal:  Biochem J       Date:  1981-01-01       Impact factor: 3.857

8.  Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors.

Authors:  C Peterson; R R Ratan; M L Shelanski; J E Goldman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

9.  Deficiency of a cholinergic differentiating factor in fibroblasts of patients with Alzheimer's disease.

Authors:  J A Kessler
Journal:  Ann Neurol       Date:  1987-01       Impact factor: 10.422

10.  Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide to a study of the inhibition by leupeptin.

Authors:  C G Knight
Journal:  Biochem J       Date:  1980-09-01       Impact factor: 3.857
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  3 in total

1.  Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation.

Authors:  Manel G Medina; Maria Dolores Ledesma; Jorge E Domínguez; Miguel Medina; Delia Zafra; Francesc Alameda; Carlos G Dotti; Pilar Navarro
Journal:  EMBO J       Date:  2005-04-21       Impact factor: 11.598

Review 2.  Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease.

Authors:  J Steven Jacobsen; Peter Reinhart; Menelas N Pangalos
Journal:  NeuroRx       Date:  2005-10

3.  Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

Authors:  J Steven Jacobsen; Thomas A Comery; Robert L Martone; Hassan Elokdah; David L Crandall; Aram Oganesian; Suzan Aschmies; Yolanda Kirksey; Cathleen Gonzales; Jane Xu; Hua Zhou; Kevin Atchison; Erik Wagner; Margaret M Zaleska; Indranil Das; Robert L Arias; Jonathan Bard; David Riddell; Stephen J Gardell; Magid Abou-Gharbia; Albert Robichaud; Ronald Magolda; George P Vlasuk; Thorir Bjornsson; Peter H Reinhart; Menelas N Pangalos
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-16       Impact factor: 11.205
  3 in total

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