Literature DB >> 16391536

The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.

Edurne Berra1, Amandine Ginouvès, Jacques Pouysségur.   

Abstract

Metazoans rapidly respond to changes in oxygen availability by regulating gene expression. The transcription factor hypoxia-inducible-factor (HIF), which controls the expression of several genes, 'senses' the oxygen concentration indirectly through the hydroxylation of two proline residues that earmarks the HIF-alpha subunits for proteasomal degradation. We review the expression, regulation and function of the HIF prolyl hydroxylases or prolyl hydroxylases domain proteins, which are genuine oxygen sensors.

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Year:  2006        PMID： 16391536      PMCID： PMC1369233          DOI： 10.1038/sj.embor.7400598

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  44 in total

1.  A conserved family of prolyl-4-hydroxylases that modify HIF.

Authors:  R K Bruick; S L McKnight
Journal:  Science       Date:  2001-10-11       Impact factor: 47.728

2.  C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Authors:  A C Epstein; J M Gleadle; L A McNeill; K S Hewitson; J O'Rourke; D R Mole; M Mukherji; E Metzen; M I Wilson; A Dhanda; Y M Tian; N Masson; D L Hamilton; P Jaakkola; R Barstead; J Hodgkin; P H Maxwell; C W Pugh; C J Schofield; P J Ratcliffe
Journal:  Cell       Date:  2001-10-05       Impact factor: 41.582

3.  Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Authors:  P Jaakkola; D R Mole; Y M Tian; M I Wilson; J Gielbert; S J Gaskell; A von Kriegsheim; H F Hebestreit; M Mukherji; C J Schofield; P H Maxwell; C W Pugh; P J Ratcliffe
Journal:  Science       Date:  2001-04-05       Impact factor: 47.728

4.  HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation.

Authors:  E Berra; D E Richard; E Gothié; J Pouysségur
Journal:  FEBS Lett       Date:  2001-02-23       Impact factor: 4.124

5.  Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm.

Authors:  E Berra; D Roux; D E Richard; J Pouysségur
Journal:  EMBO Rep       Date:  2001-07-03       Impact factor: 8.807

6.  Characterization and comparative analysis of the EGLN gene family.

Authors:  M S Taylor
Journal:  Gene       Date:  2001-09-05       Impact factor: 3.688

7.  SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons.

Authors:  E A Lipscomb; P D Sarmiere; R S Freeman
Journal:  J Biol Chem       Date:  2000-11-01       Impact factor: 5.157

8.  Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression).

Authors:  Pankaj Seth; Ian Krop; Dale Porter; Kornelia Polyak
Journal:  Oncogene       Date:  2002-01-24       Impact factor: 9.867

9.  Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact.

Authors:  Kathrin Doege; Sandra Heine; Inga Jensen; Wolfgang Jelkmann; Eric Metzen
Journal:  Blood       Date:  2005-06-09       Impact factor: 22.113

10.  FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.

Authors:  David Lando; Daniel J Peet; Jeffrey J Gorman; Dean A Whelan; Murray L Whitelaw; Richard K Bruick
Journal:  Genes Dev       Date:  2002-06-15       Impact factor: 11.361
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  55 in total

1.  Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.

Authors:  Eoin P Cummins; Edurne Berra; Katrina M Comerford; Amandine Ginouves; Kathleen T Fitzgerald; Fergal Seeballuck; Catherine Godson; Jens E Nielsen; Paul Moynagh; Jacques Pouyssegur; Cormac T Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-17       Impact factor: 11.205

2.  Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta lytic switch protein functions as a tetramer.

Authors:  Wei Bu; Kyla Driscoll Carroll; Diana Palmeri; David M Lukac
Journal:  J Virol       Date:  2007-03-28       Impact factor: 5.103

3.  Physical exercise and epigenetic modulation: elucidating intricate mechanisms.

Authors:  Helios Pareja-Galeano; Fabian Sanchis-Gomar; José Luis García-Giménez
Journal:  Sports Med       Date:  2014-04       Impact factor: 11.136

4.  Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.

Authors:  Abdo J Najy; Gregory Dyson; Bhanu P Jena; Chen-Yong Lin; Hyeong-Reh C Kim
Journal:  Am J Physiol Cell Physiol       Date:  2015-07-08       Impact factor: 4.249

5.  STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination.

Authors:  Joo Eun Jung; Hong Sook Kim; Chang Seok Lee; Yong Jae Shin; Yong Nyun Kim; Gyeong Hoon Kang; Tae You Kim; Yong Sung Juhnn; Sung Joon Kim; Jong Wan Park; Sang Kyu Ye; Myung Hee Chung
Journal:  Exp Mol Med       Date:  2008-10-31       Impact factor: 8.718

6.  PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis.

Authors:  Amandine Ginouvès; Karine Ilc; Nuria Macías; Jacques Pouysségur; Edurne Berra
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-17       Impact factor: 11.205

Review 7.  The ING gene family in the regulation of cell growth and tumorigenesis.

Authors:  Andrew H Coles; Stephen N Jones
Journal:  J Cell Physiol       Date:  2009-01       Impact factor: 6.384

8.  Prolyl-4-hydroxylase (AtP4H1) mediates and mimics low oxygen response in Arabidopsis thaliana.

Authors:  Mehar Hasan Asif; Prabodh Kumar Trivedi; Prashant Misra; Pravendra Nath
Journal:  Funct Integr Genomics       Date:  2009-03-10       Impact factor: 3.410

9.  The impact of new research technologies on our understanding of environmental causes of disease: the concept of clinical vulnerability.

Authors:  Paolo Vineis; Aneire E Khan; Jelle Vlaanderen; Roel Vermeulen
Journal:  Environ Health       Date:  2009-11-30       Impact factor: 5.984

10.  Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha.

Authors:  Mylène Heinis; Marie-Thérèse Simon; Karine Ilc; Nathalie M Mazure; Jacques Pouysségur; Raphael Scharfmann; Bertrand Duvillié
Journal:  Diabetes       Date:  2009-12-15       Impact factor: 9.461
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