Literature DB >> 16390098

Triplex formation with alpha-L-LNA (alpha-L-ribo-configured locked nucleic acid).

Niti Kumar1, Katrine E Nielsen, Souvik Maiti, Michael Petersen.   

Abstract

Using UV melting and CD spectroscopy, we show that alpha-l-LNA-modified oligonucleotides possess the ability to form triplexes at pH 6.8 with significantly increased thermostability relative to DNA triplexes.

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Year:  2006        PMID： 16390098     DOI： 10.1021/ja055483r

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  6 in total

1.  Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA.

Authors:  Sujay P Sau; Pawan Kumar; Brooke A Anderson; Michael E Østergaard; Lee Deobald; Andrzej Paszczynski; Pawan K Sharma; Patrick J Hrdlicka
Journal:  Chem Commun (Camb)       Date:  2009-10-12       Impact factor: 6.222

2.  Invader LNA: efficient targeting of short double stranded DNA.

Authors:  Sujay P Sau; T Santhosh Kumar; Patrick J Hrdlicka
Journal:  Org Biomol Chem       Date:  2010-03-04       Impact factor: 3.876

3.  Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.

Authors:  T Santhosh Kumar; Andreas S Madsen; Michael E Østergaard; Sujay P Sau; Jesper Wengel; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2009-02-06       Impact factor: 4.354

4.  C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stability.

Authors:  Pawan Kumar; Bharat Baral; Brooke A Anderson; Dale C Guenther; Michael E Østergaard; Pawan K Sharma; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2014-05-13       Impact factor: 4.354

5.  Locked nucleic acid oligomers as handles for single molecule manipulation.

Authors:  John P Berezney; Omar A Saleh
Journal:  Nucleic Acids Res       Date:  2014-08-26       Impact factor: 16.971

6.  Fluorescent intercalator displacement replacement (FIDR) assay: determination of relative thermodynamic and kinetic parameters in triplex formation--a case study using triplex-forming LNAs.

Authors:  Sujay P Sau; Pawan Kumar; Pawan K Sharma; Patrick J Hrdlicka
Journal:  Nucleic Acids Res       Date:  2012-08-01       Impact factor: 16.971
  6 in total

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