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Literature DB >> 16389827

Fluorescence-lifetime-based tomography for turbid media.

Anand T N Kumar¹, Jesse Skoch, Brian J Bacskai, David A Boas, Andrew K Dunn.

Abstract

We derive a novel algorithm to recover the in vivo distributions of fluorophores based on an asymptotic life-time analysis of time-domain fluorescence measurements with turbid tissue. We experimentally demonstrate the advantage offered by this method in localizing fluorophores with distinct lifetimes. This algorithm has wide applicability for diagnostic fluorescence imaging in the presence of several-centimeter-thick biological tissue, since fluorescence lifetime is a sensitive indicator of local tissue environment and interactions at the molecular level.

Mesh：

Year: 2005 PMID： 16389827 DOI： 10.1364/ol.30.003347

Source DB: PubMed Journal: Opt Lett ISSN： 0146-9592 Impact factor: 3.776

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Cited

27 in total

1. Analytical method for the fast time-domain reconstruction of fluorescent inclusions in vitro and in vivo.

Authors: Sung-Ho Han; Salman Farshchi-Heydari; David J Hall
Journal: Biophys J Date: 2010-01-20 Impact factor: 4.033

2. Lifetime-based tomographic multiplexing.

Authors: Scott B Raymond; David A Boas; Brian J Bacskai; Anand T N Kumar
Journal: J Biomed Opt Date: 2010 Jul-Aug Impact factor: 3.170

Review 3. Using in-vivo fluorescence imaging in personalized cancer diagnostics and therapy, an image and treat paradigm.

Authors: Y Ardeshirpour; V Chernomordik; J Capala; M Hassan; R Zielinsky; G Griffiths; S Achilefu; P Smith; A Gandjbakhche
Journal: Technol Cancer Res Treat Date: 2011-12

Fluorescence-lifetime-based tomography for turbid media.

1. Analytical method for the fast time-domain reconstruction of fluorescent inclusions in vitro and in vivo.

2. Lifetime-based tomographic multiplexing.

Review 3. Using in-vivo fluorescence imaging in personalized cancer diagnostics and therapy, an image and treat paradigm.

4. Mean time-of-flight of photons in transillumination measurements of optically anisotropic tissue with an inclusion.

5. Comparison of frequency-domain and time-domain fluorescence lifetime tomography.

6. A time domain fluorescence tomography system for small animal imaging.

7. Imaging a photodynamic therapy photosensitizer in vivo with a time-gated fluorescence tomography system.

8. Time resolved fluorescence tomography of turbid media based on lifetime contrast.

9. Fluorescence lifetime imaging system for in vivo studies.

10. A comparison between time domain and spectral imaging systems for imaging quantum dots in small living animals.