OBJECTIVE: This study was undertaken to investigate the association between congenital heart defects (CHD), and maternal homocysteine, smoking, and the MTHFR 677 C>T polymorphism. STUDY DESIGN: Plasma homocysteine concentrations, smoking status, and MTFHR 677 genotypes were determined in 275 white women who had pregnancies affected by CHDs and 118 white women who had a normal pregnancy. RESULTS: Homocysteine concentrations were significantly higher among women who had affected pregnancies (P < .0001). The highest estimated risk for having a CHD-affected pregnancy was among women who were smokers, were in the highest quartile for homocysteine, and had the MTHFR 677 CC genotype (odds ratio [OR] 11.8; 95% CI 2.6-53.3). CONCLUSION: Many CHDs are due to a complex interaction between lifestyle factors and genetic susceptibilities. Our results suggest that the combined effect of elevations in maternal homocysteine, smoking, and the MTHFR 677 C>T polymorphism increase the risk of having a CHD-affected pregnancy.
OBJECTIVE: This study was undertaken to investigate the association between congenital heart defects (CHD), and maternal homocysteine, smoking, and the MTHFR 677 C>T polymorphism. STUDY DESIGN: Plasma homocysteine concentrations, smoking status, and MTFHR 677 genotypes were determined in 275 white women who had pregnancies affected by CHDs and 118 white women who had a normal pregnancy. RESULTS:Homocysteine concentrations were significantly higher among women who had affected pregnancies (P < .0001). The highest estimated risk for having a CHD-affected pregnancy was among women who were smokers, were in the highest quartile for homocysteine, and had the MTHFR 677 CC genotype (odds ratio [OR] 11.8; 95% CI 2.6-53.3). CONCLUSION: Many CHDs are due to a complex interaction between lifestyle factors and genetic susceptibilities. Our results suggest that the combined effect of elevations in maternal homocysteine, smoking, and the MTHFR 677 C>T polymorphism increase the risk of having a CHD-affected pregnancy.
Authors: Xinyu Tang; Mario A Cleves; Todd G Nick; Ming Li; Stewart L MacLeod; Stephen W Erickson; Jingyun Li; Gary M Shaw; Bridget S Mosley; Charlotte A Hobbs Journal: Am J Med Genet A Date: 2015-04-02 Impact factor: 2.802
Authors: Laura E Mitchell; A J Agopian; Angela Bhalla; Joseph T Glessner; Cecilia E Kim; Michael D Swartz; Hakon Hakonarson; Elizabeth Goldmuntz Journal: Hum Mol Genet Date: 2014-08-18 Impact factor: 6.150
Authors: Ming Li; Stephen W Erickson; Charlotte A Hobbs; Jingyun Li; Xinyu Tang; Todd G Nick; Stewart L Macleod; Mario A Cleves Journal: Genet Epidemiol Date: 2014-03-02 Impact factor: 2.135
Authors: Ming Li; Jingyun Li; Changshuai Wei; Qing Lu; Xinyu Tang; Stephen W Erickson; Stewart L MacLeod; Charlotte A Hobbs Journal: Ann Hum Genet Date: 2015-11-27 Impact factor: 1.670
Authors: Karen Kuehl; Christopher Loffredo; Edward J Lammer; David M Iovannisci; Gary M Shaw Journal: Birth Defects Res A Clin Mol Teratol Date: 2010-02